Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Sox9 transcription factor, however, was significantly downregulated in the uPA-deficient/DSS-treated mice that developed colon adenomas as compared to the wild-type/DSS-treated group with no neoplasia identified. 31758376

2020

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA) are two serine proteases that contribute to initiating fibrinolysis by activating plasminogen. uPA is also an important tumour-associated protease due to its role in extracellular matrix remodelling. 30225958

2019

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The aim of this study was to evaluate the prognostic potential of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) tumor tissue levels and examine the association between these biomarkers and classical prognostic factors in early node-negative luminal breast cancer patients. 30646864

2019

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE The uPA expression positively correlated with gender (P = .046) and tumor size (P = .046). 30817615

2019

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Subsequently, western blot analysis was performed to investigate the expression of tristetraprolin (TTP), urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) in the xenograft tumors, and cell cultures. 29725473

2018

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE The expression of uPA was significantly correlated with the depth of invasion of esophageal cancer (<i>P</i>=0.0067), tumor size (<i>P</i>=0.0364), and pathological stage (<i>P</i><0.0001); p38MAPK expression vs esophageal cancer tissue type (<i>P</i>=0.0043), esophageal cancer infiltration depth (<i>P</i>=0.0097), tumor size (<i>P</i>=0.0015), and pathological stage (<i>P</i><0.0001). 30568465

2018

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE This may be explained by increased chemoresistance, a lower resectability and more aggressive tumor biology and tumor dissemination in patients with high uPA and PAI-1. 27345498

2017

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Urokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR): tumor expression patterns and prognostic value in oral cancer. 28841839

2017

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors. 28839232

2017

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Moreover, since uPA implications in tumor development and cancer cell invasion and metastasis, it is an attractive target for cancer chemotherapies. 28820062

2017

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE In gastric cancer, FOXM1 and uPA levels were associated with tumor size, depth of invasion, tumor-node-metastasis (TNM) stage, lymph node metastasis, vessel invasion and distant metastases. 29344165

2017

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Increased activity of uPA was documented in all tumor types. 28442916

2017

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The aim of the current study was to analyse tumour associated factors and their effect on uPAR cleavage, and the potential implications for cell proliferation, migration and invasion. 28526008

2017

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The gastric cancer specimens, which were excised from 87 patients and confirmed during July, 2012-July, 2014, were selected as observation group, and the normal tissue next to the tumor (more than 5 cm from the edge of the tumor) from 45 patients were randomly selected as control. u-PA and VEGF were detected by immunohistochemistry for the analysis of the correlation of u-PA and VEGF in two groups. 27352182

2015

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE High tumor tissue expression of uPA and uPAR is associated with poor prognosis in lung, breast, and colon cancer patients in clinical studies. 26040548

2015

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE We evaluated urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) prognostic value in postmenopausal, node-negative breast cancer patients bearing tumors with estrogen receptor (ER)/progesterone receptor (PR) expression, treated with locoregional therapy alone, within an early follow-up. 25994573

2015

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE The functional effects of miR-193b were mediated, in large part, by the concomitant increased expression of its target, urokinase-type plasminogen activator, a known tumor-associated protease. 25798837

2015

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE miR-193b directly targets STMN1 and uPA genes and suppresses tumor growth and metastasis in pancreatic cancer. 25215905

2014

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE In vivo MMP12-engineered ECFCs cleaved uPAR within the tumor mass and strongly inhibited tumor growth, tumor angiogenesis and development of lung metastasis. 25003596

2014

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Uni- and multivariate Cox's regression analysis for combined uPAR expression in tumor-associated stromal and neoplastic cells showed significant and independent negative associations with OS and DFS. 24742002

2014

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE It has been demonstrated that urokinase-type plasminogen activator (uPA) is involved in tumor cell metastasis by degrading the extracellular matrix. 23985164

2013

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE In this short report, we summarize the published data describing expression of uPA, PAI-1 and uPA receptor and their relevance to clinical and survival data in sarcomas underlining their impact as tumor biomarkers in this tumor type as well. 23734810

2013

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE IHC-based validation conducted in two independent cohorts comprising of 40 and 39 HNSCC biopsies revealed that high tumor expression of PLAU, IGFBP7, MMP14 and THBS1 were associated with inferior disease-free survival, and increased risk of disease progression or relapse. 22918226

2012

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Together, our findings show that usage of upanap-126 represents a novel multifunctional mechanistic modality for inhibition of uPA-dependent processes involved in tumor cell spread. 23038812

2012

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 GeneticVariation BEFREE Genetic polymorphism of urokinase-type plasminogen activator is interacting with plasminogen activator inhibitor-1 to raise risk of cervical neoplasia. 22354580

2012