Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Our findings suggest that in Klf4-null cells, decreased Bnip3 expression impairs mitophagy and is associated with increased mitochondrial ROS production after mitochondrial damage, providing a rationale for their genomic instability and supports a tumor suppressive role for KLF4 in certain tumors as previously observed. 31839365

2020

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Krüppel-Like Factor 4 (KLF4) is a member of the KLF transcription factor family, and evidence suggests that KLF4 is either an oncogene or a tumor suppressor. 31040909

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Here, we found that KLF4 played as a tumor-promoting gene in NPC, and could be mediated by PLK1. 31281496

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The results showed that CDK7/9 were highly expressed in UM cells, and SNS-032 significantly suppressed the cellular proliferation, induced apoptosis, and inhibited the outgrowth of xenografted UM cells and PDX tumors in NOD-SCID mice, repressed the cancer stem-like cell (CSC) properties through transcriptional inhibition of stemness-related protein Krüppel-like factor 4 (KLF4), inhibited the invasive phonotypes of UM cells through matrix metalloproteinase 9 (MMP9). 31526394

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Here, we report that Krüppel-like factor 4 (KLF4) promotes disease progression in a murine model of chronic myeloid leukemia (CML)-like myeloproliferative neoplasia by repressing an inhibitory mechanism of preservation in leukemia stem/progenitor cells with leukemia-initiating capacity. 31515251

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Furthermore, glibenclamide upregulated the expression of the tumor suppressor Krüppel-like factor 4 (KLF4), and silencing KLF4 partially reversed the inhibitory effect of glibenclamide on cell growth, EMT, and migration. 31341030

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Upon AOM and DSS treatment, KLF4 expression was progressively lost in colonic tissues of <i>Klf4<sup>fl/fl</sup></i> mice during tumor development. 30108164

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE KLF4 suppresses the tumor activity of cutaneous squamous cell carcinoma (SCC) cells via the regulation of SMAD signaling and SOX2 expression. 31284949

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Besides, we proved that miR-103 exerted its function by adjusting the expression level of the tumor-suppressor gene KLF4, and the expression level was negatively associated with miR-103. 31119790

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE KLF4 was identified to be primarily expressed in the cytoplasm of non‑tumor prostate tissues. 30747213

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Furthermore, KLF4 null cells proliferate rapidly, forming large, invasive, and osteolytic tumors when injected into mouse femurs, whereas KLF4 re-expression immediately after their intra-femoral inoculation blocks tumor development and preserves a normal bone architecture. 31239516

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 GeneticVariation BEFREE Among the tumors from the KLF4-mutated group, almost half were petroclival meningiomas. 31177425

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE In addition, our data revealed that KLF4 can facilitate the transcription of tumor suppressor TIMP3 by directly binding to the TIMP3 promoter. 31748695

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 GeneticVariation BEFREE However, the underlying regulatory mechanisms associated with the Klf4 gene as a tumor suppressor in HCC remain unclear. microRNAs (miRNAs or miRs) are a series of small non‑coding RNAs that serve a vital role in regulating gene expression via their influence on protein translation and the associated degradation of mRNA. 30664155

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE In this pilot study, we compared the combined expression of PTTG1 with KLF4 and OCT4 in seminoma, in order to validate our hypotesis that PTTG1 marks a specific population of stem cells in neoplastic tissue, strictly related with tumor. 31572301

2019

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Kruppel-like factor 4 (Klf4) was reported to have both tumor suppressive and oncogenic roles on tumorigenesis, which is depend on its subcellular localization. 29665649

2018

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Importantly, KLF4 inhibitor Kenpaullone sensitizes breast cancer cells and xenograft tumors to Paclitaxel and improves therapeutic effects. 30038266

2018

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Krüppel-like factor 4 (KLF4), a member of the KLF family of zinc finger transcription factors, has been identified as a tumor suppressor gene in a variety of tumors. 29587259

2018

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The previous study found that oncogene Klf4 played a role of tumor suppressor in the nasopharyngeal cytoplasm. 29973197

2018

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Accumulating studies have demonstrated that Krüppel-like factor 4 (KLF4) can act as a tumor suppressor or oncogene in the carcinogenesis of diverse cancers. 29940144

2018

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Cross-species analysis revealed a shared increase in human lung adenocarcinoma markers including Nkx2.1 and Napsa as well as alterations in a subset of genes with oncogenic and tumor suppressive properties such as Aurka, Ret, Klf4 and Lats2. 30412601

2018

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE These findings suggest that reducing expression or activity of the Klf4 transcription factor in tumor myeloid cells may contribute to prostate cancer therapy. 29324844

2018

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Significantly, As exposure-reduced H3K27ac and H3K4me1 inhibited the expression of genes including EP300 itself and Kruppel Like Factor 4(Klf4) that both are tumor suppressor genes. 30130555

2018

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE We observed that A375 (but not BLM) cells are able to form melanospheres and show CSCs traits: expression of the pluripotency markers SOX2 and KLF4, higher invasiveness and tumor formation capability in vivo with respect to parental adherent cells. 29330434

2018

Entrez Id: 9314
Gene Symbol: KLF4
KLF4
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE KLF4 and its downstream targets make up a gene signature that identifies indolent tumors and predicts recurrence-free survival. 30540935

2018