Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 GeneticVariation BEFREE Two coding variants, TMEM175 p.M393T (odds ratio [OR] = 1.37, p = 0.0003) and p.Q65P (OR = 0.72, p = 0.005), were associated with PD, and p.M393T was also associated with RBD (OR = 1.59, p = 0.001). 31658403

2020
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 Biomarker BEFREE Modulation of TMEM175 may impact α-synuclein biology and therefore may be a rational therapeutic strategy for PD. 31261387

2019
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 GeneticVariation GWASCAT Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms. 30957308

2019
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 Biomarker BEFREE TMEM175 has been linked to several neurodegeneration diseases, such as the Alzheimer and Parkinson disease. 29422008

2018
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci. 28892059

2017
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 Biomarker BEFREE Taken together, data from these studies suggest that TMEM175 plays a direct and critical role in lysosomal and mitochondrial function and PD pathogenesis and highlight this ion channel as a potential therapeutic target for treating PD. 28193887

2017
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 GeneticVariation BEFREE We used 2 PD case-control data sets (Washington University and the Parkinson's Progression Markers Initiative) to determine whether polymorphisms located at the GWAS top hits (GBA, ACMSD/TMEM163, STK39, MCCC1/LAMP3, GAK/TMEM175, SNCA, and MAPT) show association with AAO or motor progression. 26601739

2016
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 Biomarker BEFREE Overall, our study indicates that GBA and TMEM175/GAK significantly alter age at onset in PD. 25914293

2015
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 GeneticVariation GWASCAT Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. 25064009

2014
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815

2012
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487

2011
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 GeneticVariation GWASCAT Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. 21292315

2011
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 GeneticVariation GWASDB Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. 21292315

2011
Entrez Id: 84286
Gene Symbol: TMEM175
TMEM175
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.160 GeneticVariation GWASCAT Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487

2011