Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 AlteredExpression BEFREE Synovial sarcoma (SS) is an aggressive soft-tissue malignancy characterized by expression of SS18-SSX fusions, where treatment options are limited. 29038346

2018

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 AlteredExpression BEFREE Here, we show that SS18/SSX tightly regulates the elevated expression of the key Wnt target AXIN2 in primary SS. 26905812

2017

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 AlteredExpression BEFREE Three cases (1.5%) revealed the SYT-SSX transcript for Synovial sarcoma, and one (0.5%) a EWSR1-WT1 transcript for Desmoplastic Small Round Cell tumor. 27180056

2017

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier. 26571495

2016

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 GeneticVariation BEFREE Patients afflicted with synovial sarcoma share the fate of other translocation positive sarcomas; the driver mutation for this cancer is known, yet no means to target the fusion protein SS18-SSX directly exist. 26277104

2016

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE However, there is significant morphologic heterogeneity and overlap with a variety of other neoplasms, which can cause diagnostic challenge, particularly as the immunoprofile is varied, SS18-SSX is not detected in 100% of SSs, and they may occur at unusual sites. 25438927

2015

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE Analysis by reverse transcriptase polymerase chain reaction (RT-PCR) failed to identify the SYT-SSX1 or SYT-SSX2 fusion transcripts characteristic of synovial sarcoma. 24966982

2015

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE Proteomic studies have identified an integral role of SS18-SSX in the SWI/SNF complex, and provide new evidence for mistargeting of polycomb repression in synovial sarcoma. 25614489

2015

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 AlteredExpression BEFREE We reviewed patients with localized SS; SS18-SSX fusion transcript presence was confirmed by FISH and RT-PCR. 25613038

2015

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE The SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: relationship with extracellular matrix remodeling. 24228088

2014

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE The clinical implication of SS18-SSX fusion gene in synovial sarcoma. 24022186

2014

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE The current studies provide critical insight into our understanding of the pathogenesis of SYT–SSX-dependent synovial sarcoma and pave the way for the development of effective therapeutic agents for the treatment of the disease in humans. 23921231

2014

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma. 24166495

2014

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE SS18-SSX represents a tumor-specific target in synovial sarcoma. 23716114

2014

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE Reappraisal of TLE-1 immunohistochemical staining and molecular detection of SS18-SSX fusion transcripts for synovial sarcoma. 24422953

2014

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE Truncated SSX protein suppresses synovial sarcoma cell proliferation by inhibiting the localization of SS18-SSX fusion protein. 24130893

2014

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. 23540691

2013

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 GeneticVariation BEFREE Our new FISH assay has several advantages, including its applicability to paraffin-embedded samples, discrimination of the SS18-SSX1 and SS18-SSX2 translocations particularly in cases with aneuploidy, and potentially detecting translocations in all cases of synovial sarcoma, even with variant translocations. 23623359

2013

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. 22797074

2013

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 Biomarker BEFREE Recurrent and novel SS18-SSX fusion transcripts in synovial sarcoma: description of three new cases. 22976541

2013

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 AlteredExpression BEFREE Expression profiles of SS-related genes in hPSCs and human mesenchymal stem cells (hMSCs) were strikingly different in response to the induction of SYT-SSX, and more than half of SYT-SSX target genes in hPSCs were not induced in hMSCs. 23313505

2013

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 GeneticVariation BEFREE The synovial sarcoma X chromosome breakpoint (SSX) proteins comprise a set of cancer-testis antigens that are upregulated in MHC class I-deficient germline cells and in various types of advanced cancers with a poor prognosis. 21880588

2012

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 GeneticVariation BEFREE Synovial sarcoma is a translocation-associated sarcoma where the underlying chromosomal event generates SS18-SSX fusion transcripts. 22439931

2012

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 AlteredExpression BEFREE The RT-PCR detection of SYT-SSX fusion transcripts played a key role in establishing the diagnosis of synovial sarcoma of the cauda equina. 22098598

2012

Entrez Id: 6757
Gene Symbol: SSX2
SSX2
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma
0.700 GeneticVariation BEFREE The synovial sarcoma (SS)-associated protein, SYT-SSX2, reprograms myogenic progenitors and human bone marrow-derived mesenchymal stem cells (BMMSCs) by dictating their commitment to a pro-neural lineage. 21996728

2012