Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Recent Trends in WRN Gene Mutation Patterns in Individuals with Werner Syndrome. 28394436

2017

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation CLINVAR Sherloc: a comprehensive refinement of the ACMG-AMP variant classification criteria. 28492532

2017

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE WRNIP1 interacts with WRN helicase, which is defective in the premature aging disease Werner syndrome. 28118071

2017

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 CausalMutation CLINVAR Sherloc: a comprehensive refinement of the ACMG-AMP variant classification criteria. 28492532

2017

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE Mutations in the RecQ helicases BLM and WRN are linked to the cancer-prone disorder Bloom's syndrome and premature aging condition Werner syndrome, respectively. 23161009

2016

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation CLINVAR Exome sequencing reveals frequent deleterious germline variants in cancer susceptibility genes in women with invasive breast cancer undergoing neoadjuvant chemotherapy. 26296701

2016

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE Telomeric abnormalities caused by loss of function of the RecQ helicase WRN are linked to the multiple premature ageing phenotypes that characterize Werner syndrome. 26420422

2016

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Functional mutations in WRN cause Werner syndrome, a human autosomal recessive disease characterized by premature aging and associated with genetic instability and increased cancer risk. 26241669

2016

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer. 26690424

2016

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE After long-term cultures, WS iPSCs exhibited stable undifferentiated states and differentiation capacity, and premature upregulation of senescence-associated genes in WS cells was completely suppressed in WS iPSCs despite WRN deficiency. 25390333

2015

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 CausalMutation CLINVAR RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease. 25525159

2015

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE Cellular starvation autophagy in WS cells is restored after transfection with full length WRN. 25257404

2015

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome. 25503078

2015

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. 25931448

2015

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 CausalMutation CLINVAR Clinical utility gene card for: Werner Syndrome--Update 2014. 25182132

2015

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE We show here that lipodystrophy and extreme insulin resistance can also reveal the adult progeria Werner syndrome linked to mutations in WRN, encoding a RecQ DNA helicase. 23849162

2014

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Thus, the majority of wide and complex pathological phenotypes of WS may be explained in a unified manner by the cascade beginning with telomere dysfunction initiated by WRN gene mutation. 24356923

2014

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Werner syndrome is caused by mutations in the DNA repair Werner helicase (WRN) gene and characterized by accelerated aging including cataracts. 23334603

2014

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE Werner syndrome (WS) is a disorder characterized by features of premature aging and increased cancer that is caused by loss of the RecQ helicase WRN. 22871734

2013

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Werner syndrome (WS) is a rare autosomal recessive disorder caused by mutations in the WRN gene. 23583337

2013

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE Although WS has been characterized by a variety of clinical manifestations mimicking premature aging, the recent longevity and delayed age-associated manifestations observed both from Japanese WS and general population may suggest a common environmental effect on some gene(s) other than WRN and may give us a newer pathophysiological look at WS and also natural aging through the molecular dysfunction of WRN. 23524889

2013

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Mutations in the WRN gene cause Werner syndrome, associated with premature aging, genome instability and cancer predisposition. 22713343

2013

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 CausalMutation CLINVAR A systematic approach to assessing the clinical significance of genetic variants. 24033266

2013

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Interestingly, a WRN cDNA expression vector bearing a valine at position 114 instead of isoleucine significantly affected cholesterol efflux in WS fibroblasts. 23523974

2013

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Werner syndrome is genetically linked to mutations in WRN that encodes a DNA helicase-nuclease believed to operate at stalled replication forks. 23867477

2013