Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In addition, expression of phospho-ERK (p-ERK), NF-κB p65 (Ser536), and tumor progression-associated proteins, such as matrix metallopeptidase 9 (MMP-9), vascular endothelial growth factor (VEGF), X-linked inhibitor of apoptosis protein (XIAP), and CyclinD1 were all significantly decreased by magnolol. 31714653

2020

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In these cancers, up-regulation of trafficking and secretion of matrix metalloproteinase-9 (MMP-9), a proteolytic enzyme, is responsible for degrading the extracellular matrix, a necessary step in tumor progression. 31676484

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The changes of tumor volume, body weight, NF-κB activation, MAPK activation, and tumor progression-associated proteins (MMP-9, XIAP, VEGF, and Cyclin-D1) after regorafenib treatment were evaluated with digital caliper, digital weight, and ex vivo Western blotting assay. 30801954

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF-C) are thought to be involved in tumor progression and metastasis. 30993496

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Taken together, our findings suggest that the TGFβ1 and the MMP-9 feedback loop is critical in tumor progression, as it may aid in the development of treatment strategies that are designed to target both TGFβ and MMP-9. 31499614

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Opioids and matrix metalloproteinases: the influence of morphine on MMP-9 production and cancer progression. 30656360

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These secrete MMP-2 and MMP-9 that promote tumor progression. 29727510

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Herein we describe construction of a nanosensor for matrix metalloproteinase 9 (MMP9), which is associated with tumor progression and metastasis, for detection of colorectal cancer in a mouse model. 30059042

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Functional analysis through shRNA-mediated stable knockdown of SMAD4 in microglia revealed the downregulation of the expression of matrix metalloproteinase 9 (MMP9), which has been shown to be involved in tumor progression and cell migration. 29861845

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The expression of mRNA and proteins involved in migration and cancer progression [epithelial cell adhesion molecule, intercellular adhesion molecule-1, β-catenin, N-cadherin, E-cadherin, matrix metalloproteinase (MMP)-2 and MMP-9] was determined by reverse transcription-quantitative polymerase chain reaction and western blot analysis. 30066850

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Matrix metalloproteinase-9 (MMP-9) is known to play a central role in tumor progression and invasion. 29134466

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE One enzyme with proteolytic activity reported to be involved in tumor progression and assumed to be enhanced in the tumor environment is the matrix metalloproteinase 9 (MMP-9). 30274515

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Importantly, TIPE1 dramatically restrained the expression and activities of MMP2 and MMP9 which are demonstrated to promote tumour progression and are implicated in EMT. 28994231

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE MMP-9 plays important roles in the breakdown of the extracellular matrix and in the facilitation of tumor progression, invasion, metastasis, and angiogenesis. 28122987

2017

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Combined GM-CSF neutralization and MMP9 inhibition synergistically reduced angiogenesis and tumor progression. 28754674

2017

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In addition, silencing of CtBP2 markedly increased the apoptosis of PCa cells in vitro, and decreased the expression of IL-8, AT2R, CCND1 and MMP9 which are associated with cancer progression. 28677795

2017

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Moreover, the subsequent mechanism investigation suggested that CAPN2 promoted tumor progression by activating AKT/mTOR signaling, enhancing epithelial mesenchymal transition (EMT) and MMP9 levels. 29228653

2017

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The mRNA or protein level of TOPK, toll- like receptor4 (TLR4), interleukin (IL)-6, vascular endothelial growth factor (VEGF) or matrix metalloproteinase9 (MMP9) genes related to TLR4 signaling or tumor progression was induced by LPS treatment in MCF7 breast cancer cells, but the induction was abolished by stable knocking down of TOPK in MCF7 cells. 28212583

2017

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE High-mobility group protein two (HMGA2), a nonhistone nuclear-binding protein and its downregulators; vimentin, matrix metallopeptidase-9 (MMP-9), and E-cadherin are shown to contribute to tumor progression and metastasis. 27188536

2017

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE The correlation of MMP9 expression with tumor progression was explored in glioma specimens of all grades. 27022952

2016

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Gelatinase B (-1562C/T) polymorphism in tumor progression and invasion of breast cancer. 24357512

2014

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Although there is little research on MMP-9 dimers, some studies have shown the dimer to be associated with more aggressive tumor progression. 24378964

2014

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These data suggest that in vivo MMP9-mediated processing of HSPB1 acts to regulate VEGF-induced ECs activation for tumor progression, releasing anti-angiogenic HSPB1 fragments. 24465581

2014

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Matrix metalloproteinase 9 (MMP-9) is a type-IV collagenase that is highly expressed in breast cancer, but its exact role in tumor progression and metastasis is unclear. 24845596

2014

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Both MMP-2 and MMP-9 have role in cancer progression and remodelling of the ectocervix. 24804816

2014