Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The IL-6/STAT3 pathway is a key regulator of genes involved in cancer progression. 31850822

2020

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE STAT3-induced upregulation of lncRNA ABHD11-AS1 promotes tumour progression in papillary thyroid carcinoma by regulating miR-1301-3p/STAT3 axis and PI3K/AKT signalling pathway. 30657221

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Oncogene-induced STAT3-activation is central to tumor progression by promoting cancer cell expression of pro-angiogenic and immunosuppressive factors. 31766350

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Since signal transducer and activator of transcription 3 (STAT3) is aberrantly activated in hepatocellular carcinoma (HCC) and plays a key role in this tumor progression. 30585547

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Abnormal activation of signal transducer and activator of transcription 3 (STAT3) is complicated in the tumor progression of multiple cancers including human head and neck squamous cell carcinoma (HNSCC) and, therefore, serves as a potent therapeutic target. 30870229

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Taken together, these results indicate that TNF-α and IFN-γ pretreatment effectively inhibited the repair ability of MSCs and accelerated inflammation and tumor progression involving NF-κB/STAT3 pathway and angiogenesis-related factors. 31632588

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Excessive STAT3 activation within cancer cells and cells of the tumour microenvironment can be viewed as a neoplastic mimic of an inflammation-driven repair response that collectively promotes tumour progression. 30578415

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE It suggests that STAT3 could serve as a potential target to impair tumor progression or recurrence. 30958597

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Hepatic Stress Response in HCV Infection Promotes STAT3-Mediated Inhibition of HNF4A-<i>miR-122</i> Feedback Loop in Liver Fibrosis and Cancer Progression. 31547152

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Newly formed NETs directly upregulated the Toll-like receptor 9 (TLR9) pathways in DLBCL and subsequently activated NFκB, STAT3, and p38 pathways to promote tumor progression. 30446590

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In addition, gene knockdown and RNAseq were used to investigate molecular mechanisms through which STAT3 regulates tumor progression and the survival in lung cancer. 31619200

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Mounting evidence has revealed that STAT3 is aberrantly activated in many malignant tumors and plays a critical role in cancer progression. 31213912

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Accumulating evidence indicates that these tolerogenic properties are highly regulated by the constitutive and persistent activation of the oncogenic signal transducer and activator of transcription 3 (STAT3) protein, which impairs anti-tumor immunity and enhances tumor progression. 31698775

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Cancer mutations and epigenetic alterations may alter the balance between pro-oncogenic and tumor suppressor activities associated with STAT3/5 signaling, explaining their context-dependent association with tumor progression both in human cancers and animal models. 31557897

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In this review we will focus on the role of STAT3 and its regulation, e.g. by phosphorylation or acetylation in immune cells and how it might impact immune cell function and tumor progression. 31480382

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Aberrant STAT3 activation triggers tumor progression through oncogenic gene expression in numerous human cancers, leading to promote tumor malignancy. 31186087

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE STAT family members notably STAT3 and STAT5 have been involved in cancer progression whereas STAT1 plays opposite role by suppressing tumor growth. 30847297

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In conclusion, our data suggested that for HSCC patients, AIM2 and p‑STAT3 expression detected via IHC could serve as a biomarker to predict tumor progression and as an independent prognostic factor. 30816544

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE This TRF2-dependent regulation facilitated the recruitment of MDSCs, their activation via the TLR2/MyD88/IL-6/STAT3 pathway leading to the inhibition of natural killer recruitment and cytotoxicity, and ultimately tumor progression and metastasis. 31000523

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells Via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor. 30587839

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 PosttranslationalModification BEFREE Our results imply a mechanism in which quantitative differences of STAT3 Tyr705 phosphorylation, as compared with other activation modes, direct discrete outcomes in tumor progression. 30135074

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE STAT3 promotes tumour progression in glioma by inducing FOXP1 transcription. 30134017

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Activated STAT3 persistently triggers tumor progression through direct regulation of oncogenic gene expression. 29222039

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Signal transducers and activators of transcription-3 (STAT3) is constitutively activated in MB where it functions as an oncoprotein, mediating cancer progression and metastasis. 29280516

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Th17 cell-derived IL-17A promoted tumor progression via STAT3/NF-κB/Notch1 signaling in non-small cell lung cancer. 30377557

2018