Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE Mutations in the PARK2 and PARK6 genes, coding for the cytosolic E3 ubiquitin protein ligase Parkin and the mitochondrial serine/threonine kinase PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1], lead to clinically similar early-onset Parkinsonian syndromes. 25849933

2016

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 Biomarker CTD_human Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells. 26558463

2016

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE Mutations of parkin gene are not restricted to familial forms of Parkinsonism but they also occur in a wide variety of malignancies including gliomas. 26238155

2016

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 Therapeutic CTD_human Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells. 26558463

2016

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 Biomarker CTD_human A recurrent mutation in PARK2 is associated with familial lung cancer. 25640678

2015

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 Therapeutic CTD_human A recurrent mutation in PARK2 is associated with familial lung cancer. 25640678

2015

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 Biomarker BEFREE PARK2 (PARKIN) is an E3 ubiquitin ligase whose dysfunction has been associated with the progression of Parkinsonism and human malignancies, and its role in cancer remains to be explored. 25877876

2015

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 Biomarker BEFREE PINK1 and PARKIN are causal genes for hereditary Parkinsonism. 23751051

2014

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE PINK1 (PTEN induced putative kinase 1) and PARKIN (also known as PARK2) have been identified as the causal genes responsible for hereditary recessive early-onset Parkinsonism. 24784582

2014

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 Biomarker BEFREE Dysfunction of PARK2 is associated with the progression of parkinsonism. 24297497

2014

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE Mutations in the Parkin gene (PARK2) are the major cause of autosomal recessive early-onset parkinsonism. 24244333

2014

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal recessive juvenile-onset and young-onset parkinsonism. 23459986

2013

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 Biomarker CTD_human Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism. 23046578

2013

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 Therapeutic CTD_human Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism. 23046578

2013

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE In three forms, caused by mutations in parkin (PARK2), PINK1 (PARK6), or DJ-1 (PARK7), the phenotype is usually characterized by levodopa-responsive parkinsonism without atypical features. 22166450

2012

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. 22431710

2012

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE On the other hand, the recessively inherited early-onset Parkinsonism is caused in about half of the cases with loss-of-function mutations in PARK2, which encodes E3 ubiquitin ligase parkin in the ubiquitin-proteasome system. 20221696

2011

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 Biomarker BEFREE On careful review, we found the FBXO7 cases to have a phenotype more similar to PRKN gene associated parkinsonism. 20669327

2010

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE Mutations of the parkin gene on chromosome 6 cause early-onset parkinsonism. 19922375

2010

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE Parkin gene mutations are the most common cause of early-onset parkinsonism. 20625164

2010

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE Using serial (18)F-dopa PET, the present longitudinal study addresses rates of progression of nigrostriatal dysfunction in both compound heterozygous (parkin-linked parkinsonism) and single heterozygous parkin gene carriers. 19845000

2010

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE Genetic screening reveals high frequency of PARK2 mutations and reduced Parkin expression conferring risk for Parkinsonism in North West India. 19734163

2010

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE Nonmotor symptoms in Parkin gene-related parkinsonism. 20629119

2010

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE The mutations in the parkin gene can lead to a loss of function of parkin and cause autosomal recessive juvenile onset parkinsonism. 20889974

2010

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.500 GeneticVariation BEFREE Although mutations in the parkin gene are frequently associated with familial Parkinsonism, emerging evidence suggests that parkin also plays a role in cancers as a putative tumor suppressor. 20630868

2010