Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 Biomarker BEFREE Identification of CD5/Cyclin D1 Double-negative Pleomorphic Mantle Cell Lymphoma: A Clinicopathologic, Genetic, and Gene Expression Study. 31688139

2020

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 AlteredExpression BEFREE Regulation of SOX11 expression through CCND1 and STAT3 in mantle cell lymphoma. 30530749

2019

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 AlteredExpression BEFREE In conclusion, we report 3 cases of nodal PMBL, 2 of them without mediastinal mass, and expression of cyclin D1 due to copy number gains of CCND1 gene, a diagnostic pitfall with mantle cell lymphoma and DLBCL, not otherwise specified. 30211726

2019

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 Biomarker BEFREE When cyclin D1 was overexpressed by the Eμ-cyclin D1 transgene, ATA B cells progressed to further diffused lymphoma in aged mice, including in various lymph nodes with accumulation of IgM<sup>hi</sup>IgD<sup>lo</sup>CD5<sup>+</sup>CD23<sup>-</sup>CD43<sup>+</sup> cells, resembling aggressive human mantle cell lymphoma. 29898964

2018

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 AlteredExpression BEFREE Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA. 30180865

2018

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 AlteredExpression BEFREE Cyclin D1 mRNA as a molecular marker for minimal residual disease monitoring in patients with mantle cell lymphoma. 29273915

2018

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 AlteredExpression BEFREE In addition, cyclin D1 overexpression sensitized cells to transcription inhibitors, revealing a synthetic lethality interaction that was also observed in primary mantle cell lymphoma cases. 29990311

2018

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 Biomarker BEFREE Cyclin D1 depletion induces DNA damage in mantle cell lymphoma lines. 27338091

2017

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 Biomarker BEFREE Cyclin D1-positive tumor cells are commonly found in mantle cell lymphoma but they are very rare in diffuse large B-cell lymphoma. 28296741

2017

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 Biomarker BEFREE Role of SOX11 and Genetic Events Cooperating with Cyclin D1 in Mantle Cell Lymphoma. 28466437

2017

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 GeneticVariation BEFREE Mantle cell lymphoma with a novel t(11;12)(q13;p11.2): a proposed alternative mechanism of CCND1 up-regulation. 28132860

2017

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 AlteredExpression BEFREE Cyclin D1 protein expression in lymphocytes is classically associated with mantle cell lymphoma. 28038705

2017

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 GeneticVariation BEFREE CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma. 27713153

2016

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 Biomarker CTD_human Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas. 26174628

2016

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 GeneticVariation BEFREE Translocation t(11;14)(q13;q32) CCND1-IGH is typically associated with mantle cell lymphoma or a subset of plasma cell myeloma and is exceedingly rare in myeloid neoplasm. 27810077

2016

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 Biomarker BEFREE Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma. 27025456

2016

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 Biomarker BEFREE Quantitative PCR detection of t(11;14) bcl-1/JH in mantle cell lymphoma patients: comparison of peripheral blood and bone marrow aspirate samples. 26744872

2015

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 GeneticVariation BEFREE Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia. 26261659

2015

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 GeneticVariation BEFREE Unusual concomitant rearrangements of Cyclin D1 and MYC genes in blastoid variant of mantle cell lymphoma: Case report and review of literature. 23313364

2013

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 Biomarker BEFREE CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma. 23255553

2013

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 AlteredExpression BEFREE Cyclin D1 (CCND1) messenger RNA expression as assessed by real-time PCR contributes to diagnosis and follow-up control in patients with mantle cell lymphoma. 24060591

2013

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 Biomarker BEFREE Cyclin D1-negative mantle cell lymphoma. 23429984

2013

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 AlteredExpression BEFREE The recognition of cyclin D1 expression in PC of a significant minority of CLL/SLL can be a diagnostic aid and should not lead to the diagnosis of focal mantle cell lymphoma. 22706868

2012

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 AlteredExpression BEFREE Mantle cell lymphoma is a B cell malignancy in which constitutive dysregulation of cyclin D1 and the cell cycle, disruption of DNA damage response pathways, and activation of cell survival mechanisms contribute to oncogenesis. 23023712

2012

Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400 Biomarker BEFREE Flipping the cyclin D1 switch in mantle cell lymphoma. 22687450

2012