×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
Computational analysis of high-risk SNPs in human CHK2 gene responsible for hereditary breast cancer : A functional and structural impact.
31398194
2019
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
Biomarker
BEFREE
Hence, our approach allowed us to specify BC relative risks associated with deleterious-predicted variants in PALB2, ATM and CHEK2 and to add MAST1, POLH, RTEL1 and FANCI to the list of DNA repair genes possibly involved in BC susceptibility.
30303537
2019
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
The most important cause of developing hereditary breast cancer is germline mutations occurring in breast cancer (BCs) susceptibility genes, for example, BRCA1, BRCA2, TP53, CHEK2 , PTEN, ATM, and PPM1D.
30552672
2019
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
A novel CHEK2 variant identified by next generation sequencing in an Indian family with hereditary breast cancer syndrome.
31296309
2019
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
Biomarker
BEFREE
Compared with control datasets, predicted damaging rare missense variants were significantly more prevalent in CHEK2 and TP53 in BC index patients.
29522266
2018
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
Biomarker
CLINGEN
Increased Risk for Other Cancers in Addition to Breast Cancer for CHEK2*1100delC Heterozygotes Estimated From the Copenhagen General Population Study.
26884562
2016
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
Biomarker
CLINGEN
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
27595995
2016
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
However, only about 20% of familial breast cancer is attributed to mutations in BRCA1 and BRCA2, while a further 5-10% are attributed to mutations in other rare susceptibility genes such as TP53, STK11, PTEN, ATM and CHEK2 .
25736863
2015
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
However, only about 20% of familial breast cancer cases are attributed to mutations in BRCA1 and BRCA2, while a further 5-10% are attributed to mutations in other rare susceptibility genes such as TP53, STK11, PTEN, ATM and CHEK2 .
25936246
2015
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
The present study indicates that the CHEK2 c.1100delC mutation does not contribute substantially to hereditary breast cancer in patients of Greek descent.
25835597
2015
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
Biomarker
CLINGEN
A risk of breast cancer in women - carriers of constitutional CHEK2 gene mutations, originating from the North - Central Poland.
24713400
2014
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
Biomarker
BEFREE
One gene that is commonly included on NGS hereditary breast cancer panels is CHEK2 .
25355026
2014
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
We conclude that the tumor-specific loss of the wild-type allele is not characteristic for BC arising in CHEK2 , NBN/NBS1 and BLM mutation carriers.
24415413
2014
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
First evidence of a large CHEK2 duplication involved in cancer predisposition in an Italian family with hereditary breast cancer .
24986639
2014
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
Germ line CHEK2 mutations are seen in a subset of patients with a familial breast cancer and sarcoma phenotype.
24595525
2014
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
Genotyping for the CHEK2 ∗1100delC mutation in a familial breast cancer setting contributes to optimal clinical surveillance in countries in which this mutation is prevalent.
23415889
2013
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
Response to DNA damage of CHEK2 missense mutations in familial breast cancer .
22419737
2012
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
Biomarker
CLINGEN
Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications.
21542898
2011
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
CHEK2 gene mutations occur in a subset of patients with familial breast cancer , acting as moderate/low penetrance cancer susceptibility alleles.
21562711
2011
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
We investigated the contribution of CHEK2 mutations to non-BRCA HBC by direct sequencing of its whole coding sequence in 507 non-BRCA HBC cases and 513 controls.
22114986
2011
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
Biomarker
CLINGEN
Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer.
21876083
2011
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
Mutations in the recognized breast cancer susceptibility genes BRCA1, BRCA2, TP53, ATM, and CHEK2 account for approximately 20% of hereditary breast cancer .
21409391
2011
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
Breast cancer low-penetrance allele 1100delC in the CHEK2 gene: not present in the Chinese familial breast cancer population.
18484200
2008
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
CHEK2 1100delC was genotyped in the index cases of 369 Dutch colorectal cancer families that had been excluded for familial breast cancer .
18676774
2008
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Breast Cancer, Familial
0.400
GeneticVariation
BEFREE
CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer .
17705858
2007