Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 GeneticVariation BEFREE Functional Variant rs4442975 Modulating FOXA1 Binding Affinity Can Influence Bone Marrow Suppression during Neoadjuvant Chemotherapy for Luminal A Type Breast Cancer. 30881995

2019

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE The analysis revealed already well-established associations with XBP1 and FOXA1, but also identified a strong association with CT62, a potential immunotherapeutic target with few previous associations with breast cancer. 30760519

2019

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE This is in line with other studies suggesting these SNPs as risk-associated polymorphisms which may lead to a change in the affinity of FOXA1, as a distal enhancer, to <i>TOX3</i> and thus change in <i>TOX3</i> expression, which can eventually affect the risk of breast cancer. 31338012

2019

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer. 31562808

2019

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer. 31826955

2019

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Altered FOXA1 levels contribute to endocrine-resistant breast cancer, where it maintains ER-chromatin interactions, even in contexts in which cells are refractory to ER-targeted drugs. 30840881

2019

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer. 31644911

2019

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE Genetic ablation of mammary ducts through foxa1 prevents breast cancer occurrence. 30906639

2019

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE Overall, our results indicate that FOXA1 could be a useful biomarker to predict prognosis in breast cancer patients. 30941644

2019

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE FOXA1 was reported to facilitate or reprogram ERα binding, thus playing a key function in breast cancer progression. 31029427

2019

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Breast cancer metastases (n = 164) from various anatomical sites were retrospectively analyzed by immunohistochemistry for FOXA1, Nestin and GATA3 expression. 30819139

2019

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Further, we demonstrated that FOXA1 attenuation was involved in transcriptional downregulation of proapoptotic Bim and thus suppressed breast cancer cell apoptosis. 30793308

2019

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer. 29758547

2018

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE FOXA1 levels are decreased in pleural breast cancer metastases after adjuvant endocrine therapy, and this is associated with poor outcome. 29972720

2018

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE Here in this study, we aimed to identify which are the proteins that could potentially control FOXA1 function in breast cancer cell lines expressing different molecular markers. 30572598

2018

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE It was found that forkhead box protein A1 (FOXA1) is abnormally expressed in various tumors, such as breast cancer, ovarian cancer, and is closely related to tumorigenesis. 30468461

2018

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 GeneticVariation BEFREE Biological assays indicated that the germline G>T variation at rs6506689 creates a FOXA1-binding site and up-regulates the expression of RAB31, thus playing an important role in the development of BC. 30182384

2018

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE These results suggest that miR-132 and FOXA1 may be potential biomarkers or therapeutic targets in breast cancer. 28816236

2018

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE In this study, we determined the impact of OGT on expression of EZH2 target genes FOXA1 and FOXC1, that are involved in breast cancer progression. 29864144

2018

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Immunohistochemical expression of AR and FOXA1 was evaluated on 479 consecutive BC, with complete clinical-pathological and follow up data. 29970021

2018

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE Stable expression of FOXA1, but not ERα, reduced the expression of <i>IL6</i> in the FOXA1- and ERα-negative breast cancer MDA-MB-231 cells and TAM-R cells, without affecting the activation of the NF-κB signaling pathways. 28270510

2017

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE FOXA1, a known driver of hormone-receptor positive breast cancer, harbours a mutational hotspot in its promoter leading to overexpression through increased E2F binding. 28658208

2017

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Forkhead box A1 (FOXA1), a transcription factor, plays a crucial role in breast cancer and has been predicted as a target of miR-204. 28534958

2017

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Elevated <i>FOXA1</i> expression in BC also facilitates hormone responsiveness in estrogen receptor (<i>ESR</i>)-positive BC. 28789340

2017

Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE In contrast, constitutive (MYC, TBX3) and signal-induced (TP53, FOXA1) DB-TFs that do not mediate default repression are directly altered in breast cancer. 28215225

2017