Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Mechanically, TIPE1 directly targets β-catenin and promotes β-catenin degradation in a protease-dependent manner, and Wnt/β-catenin signaling plays a crucial role during TIPE1-mediated stemness inhibition in colon cancer. 31111874

2020

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE The expression of β-catenin and STT3A/B in colon cancer tissues was initially detected by immunohistochemistry, followed by correlation analyses of the survival rate with the expression of β-catenin and STT3A/B as well as identification of the interaction between β-catenin and STT3A/B. 31812723

2020

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE The selective ERα antagonist could significantly decrease Wnt2b/LRP8/Dvl1 expression, increase destruction complex (Axin2/GSK3a/APC) expression, and promote degradation of β-catenin in colon carcinoma cell by inhibited NLRP3 expression. 31121307

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE In conclusion, targeting CBP/β-catenin, combined with PD-1/PD-L1 immune checkpoint blockade, shows potential as a new therapeutic strategy for treating liver metastasis during colon cancer. 31105882

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE In addition, PIK3CD expression in colon cancer tissues positively correlated with β-catenin abnormal expression, which was an independent predictor for OS of colon cancer patients. 30618098

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE We analyzed the correlation between ACLY and CTNNB1 protein in 78 colon cancer patients by Pearson correlation. 31511060

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Metformin-activated AMPK regulates β-catenin to reduce cell proliferation in colon carcinoma RKO cells. 30854043

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE <i>Conclusion</i>: ZEB2-AS1 could promote colon cancer cell proliferation and inhibit apoptosis to promote the progression of colon cancer by upregulating the expression of β-catenin protein. 31698657

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Nuclear Accumulation of β-Catenin in Cancer Stem Cell Radioresistance and Stemness in Human Colon Cancer. 31810923

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE In this study, we synthesized Dicer-substrate siRNA conjugated with palmitic acid at the 5'-end of the sense strand (C16-DsiRNA), and examined its RNAi effect on β-catenin as a target gene in a colon cancer cell line, HT29Luc, both in vitro and in vivo. 30560565

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression: implications in colon cancer. 31351496

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE By an in silico study, we present here a possible mechanism of interaction between the sesame lignans and β-catenin leading to inhibition of formation of the said complex, thereby elevating some of these ligands as potential lead molecules in the development of drugs for treatment of colon cancer. 29455637

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Selective Wnt/β-catenin Small-molecule Inhibitor CWP232228 Impairs Tumor Growth of Colon Cancer. 31262892

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE We propose that inhibition of the WNT pathway, particularly β-catenin, may bypass resistance to MEK inhibition in human PIK3CA mt colon cancer. 30944457

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE PRRX2 and β-catenin in patients with the liver metastases of colon cancer was detected by immunochemistry. 31471104

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE Colon cancer cells secrete and express high levels of β-catenin, which may stimulate autocrine signaling and further enhance activities of the canonical Wnt signaling pathway. 29808797

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE MiR-155 directly regulates β-catenin at the transcriptional level, and promotes the invasion potential of colon cancer cell, at least partly through the upregulation of β-catenin. 29364476

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 PosttranslationalModification BEFREE Here, we aimed to investigate whether epigenetic silencing of β-catenin induces human colon cancer cell migration and/or invasion. 29923144

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE The human PKP2/plakophilin-2 gene is induced by Wnt/β-catenin in normal and colon cancer-associated fibroblasts. 29044515

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE A Positive Feed-Forward Loop between LncRNA-CYTOR and Wnt/β-Catenin Signaling Promotes Metastasis of Colon Cancer. 29606502

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Overall, the current study has identified activation of the Wnt/β-catenin pathway as a novel fundamental cause of colon cancer resistance to BRAF inhibition. 29167314

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Tetrac downregulates β-catenin and HMGA2 to promote the effect of resveratrol in colon cancer. 29255096

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE RPIA modulates cell proliferation and oncogenicity via activation of β-catenin in colon cancer cell lines. 29337987

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE KLF4 Mediates the Effect of 5-ASA on the β-Catenin Pathway in Colon Cancer Cells. 29794245

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Our results establish MACC1 as a transcriptional target of Wnt/β-catenin signaling and suggest that DBC1 plays a key role in colorectal cancer progression through Wnt/β-catenin-MACC1 signaling axis. 30082743

2018