Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE Ulcerative colitis (UC) is an important risk factor for the occurrence of colon cancer, and changes in expression of p53 and inflammatory factors are closely related to the pathogenesis of colon cancer. 30906432

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE In this study, two <i>TP53</i> mutations, corresponding to exon 3 (TP53E3) and 10 (TP53E10), were generated in LS174T cells derived from a wild-type TP53 human colon cancer via a lentiviral CRISPR-Cas9 system. 30988165

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE Here we sought to investigate the role of miR-150-5p-TP53 signaling pathway in proliferation of colon cancer and to determine expression levels of miR-miR-150-5p and TP53 in colon adenocarcinoma and adjacent non-cancerous tissue samples, or in human colon adenocarcinoma cell lines. 31043658

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE As loss of p53 in colon cancer cells contributes to resistance against anticancer drugs, and thus to reoccurrence of colon cancer, targeted delivery of silica NPs could be envisioned to also deplete p53 deficient tumor cells. 31426331

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE Quinaldic acid induces changes in the expression of p53 tumor suppressor both on protein and gene level in colon cancer LS180 cells. 30780127

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE These results suggest that a high dose of glyceollins possibly promotes the growth of p53 wild-type colon cancer through activation of the Nrf2-mediated signaling pathway and, in particular, strong induction of HO-1 expression. 30924710

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE We also found that CDKN1A expression in mutant p53 colon cancer tissue was significant decreased when compared with p53 wild type colon cancer tissue, while Wnt ligand Wnt5a exhibited the highest level in p53 mutant colon cancer tissue. 30833076

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Our findings suggest that protopine exerts its antiproliferative activity by stimulating the p53 pathway and may have potential as a chemopreventive agent for human colon cancer. 30932278

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 GeneticVariation BEFREE We found that both PHD3 and PHD3-H196A suppress the expression of the stem cell-associated gene NANOG and inhibited the properties of colon cancer stem cells through p53. 31092600

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Mutant p53 in colon cancer. 30496442

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 GeneticVariation BEFREE The effects of exosomes on tumor growth were evaluated using human cell lines (TP53-WT colon cancer, HCT116; TP53-mutant colon cancer, HT29; and fibroblasts, CCD-18Co and WI-38) and an immune-deficient nude mouse xenograft model. 31148360

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE Recent study indicated that BP5 significantly stimulates expression of p53 protein in colon cancer HCT116 cells. 31123429

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 GeneticVariation BEFREE However, TP53 mutations were more prevalent in colon cancer with KRAS mutations than in rectal cancer (75.0% vs 28.6%, respectively, p = 0.004). 31729406

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE The cytotoxicity of RH1 was inhibited in A549 cells treated with the p53-inhibitor pifithrin-α or transfected p53 siRNA and in human colon cancer HCT116 isogenic (p53<sup>-/-</sup>) cells. 30879173

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Here, enterolacton, S-equol and urolithin A as representatives of metabolites of lignans, isoflavones and ellagitannins, respectively, were examined for their impact on HCT116 colon cancer cell growth, cooperativity with oxaliplatin and p53 dependency in vitro. 30418550

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE To investigate the molecular mechanisms of cordycepin against colon cancer and in driving apoptosis, p53 and Bcl‑2‑like protein 4‑null (Bax‑/‑) colon cancer HCT116 cell lines were used. 30535479

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE Here, we have investigated ASAH1 expression at the protein level in human colon cancer cell lines and tissues from colon cancer patients, and have examined in vitro the possible link between ASAH1 expression and functional activity of p53 protein whose inactivation is associated with the progression from adenoma to malignant tumour in colon cancer. 29920241

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 GeneticVariation BEFREE This study found an association between alterations in the TP53 gene and the synergy score for combination treatment with doxorubicin and an Src kinase inhibitor using human osteosarcoma cell lines (MG63 and U2OS) and human colon cancer cell line. 30124118

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE Results demonstrate that milimolar concentrations of butyrate has an anti-proliferative effect in all three colon cancer cell lines under study, leading to a decrease on cell viability, expression of P21, P53 and β-catenin, being able to modulate P-glycoprotein activity and to induce apoptosis by modulation of BAX/BCL-2 ratio. 29587241

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Surface-Enhanced Raman Scattering (SERS) is used to differentiate two colon cancer cell line HCT 116, that is, to distinguish a TP53 gene knockout cell line (p53 -/-) from a wild type (p53 +/+). 30059864

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE <b>Conclusions:</b> These results indicate that G9a-induced and p53-dependent epigenetic programing stimulates the growth of colon cancer, which also suggests that G9a inhibitors that restore p53 activity are promising therapeutic agents for treating colon cancer, especially for CRC expressing wild-type p53. 29774081

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Utilizing human colon carcinoma HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures, the roles of inter- and intracellular ROS signaling on expression of the adaptive response as evidenced by changes in intracellular translocation of survivin measured by ELISA, and cell survival determined by a standard colony forming assay were investigated using ROS modifying agents that include emodin, N-acetyl-L-cysteine (NAC), fulvene-5, honokiol, metformin and rotenone. 29660403

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Three different reviewers, with varying experience of digital pathology and image analysis, applied an agreed QuPath scoring methodology to CD3 and p53 immunohistochemically stained TMAs from a colon cancer cohort (n = 661). 29575153

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE The tumor suppressor protein p53 plays an important role in the development and progression of colon cancer, and the subcellular organelle localization directly affects its function. 30532707

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 GeneticVariation BEFREE These findings suggest that 6-MSITC might be a potential agent for colon cancer chemoprevention although with p53 mutation.© 2018 BioFactors, 2018. 29756671

2018