Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 Biomarker BEFREE Thus, the pharmacological inhibition of Skp2 may prove to be a novel therapeutic strategy with which to overcome drug resistance in OS. 29620168

2018
Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 Biomarker BEFREE Together, our findings suggest that Skp2 is a promising therapeutic target in osteosarcoma, and that FKA may be an effective Skp2-targeted therapy to reduce osteosarcoma metastasis. 30250282

2018
Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 Biomarker BEFREE Moreover, we observed that depletion of Skp2 triggered cell apoptosis in two OS cell lines. 28627672

2017
Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 Biomarker BEFREE In conclusion, our study demonstrated that Skp2 exhibited an oncogenic function in OS cells, suggesting that inhibition of Skp2 may be a novel approach for the treatment of OS. 28771075

2017
Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 Biomarker BEFREE Western analysis suggested that saurolactam treatment resulted in a reduction of Akt/PKB, phospho-Ser473-Akt, c-Myc, and S-phase kinase-associated protein 2 (Skp2) in MG-63 and HOS osteosarcoma cells. 25627547

2015