Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Signaling pathways of VEGFs and PDGFs are crucial in tumor angiogenesis, which is essential in solid tumor progression and metastasis. 28561780

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE VEGF siRNA delivered by polycation liposome-encapsulated calcium phosphate nanoparticles for tumor angiogenesis inhibition in breast cancer. 28860767

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE In the tumors of the nervous system, VEGF plays a critical role in tumor angiogenesis and tumor progression. 28911884

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Both CRAds were also tested along with anti-VEGF monoclonal antibody Avastin and showed no significant augmentation of viral cytolysis by anti-angiogenesis treatment in vitro. 27349517

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Vascular endothelial growth factor receptors (VEGFRs) are the major receptors involved in endothelial cell-dependent tumor angiogenesis. 28359326

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE The synergistic tumor suppression elicited by AdVING4/PTEN was closely associated with the synergistic induction of apoptosis possibly via enhancement of endogenous p53 responses through cooperatively facilitating p53's stability and acetylation, and the synergistic inhibition of tumor angiogenesis probably via overlapping reduction of VEGF through cooperatively downregulating hypoxia inducible factor-1α's level and transcription activity. 26564429

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Inhibitor of DNA binding (ID) proteins are transcriptional targets of TGF-β1 and ID1 has been implicated in VEGF-A regulation during tumor angiogenesis. 26577912

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression BEFREE Integrated analyses demonstrated significant associations between increased vascular proliferation, amplification of the 6p21 region, VEGF-A mRNA expression, and the 32-gene angiogenesis signature. 25860936

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression BEFREE However, how transcription factors interact with histone-modifying enzymes to regulate VEGF transcription and tumor angiogenesis remains unclear. 26848522

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Vascular endothelial growth factor (VEGF), which can be induced by chronic inflammation, plays a pivotal role in tumor angiogenesis as well as tumor growth and metastasis. 26004415

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression BEFREE Here we show that EPCs (MAgEC11.5) target tumor angiogenesis and allow local overexpression of hypoxia-driven soluble VEGF-receptor2 enabling drastic tumor growth reduction. 26577811

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression BEFREE It mediates downstream hypoxia-inducible factor 1α accumulation in the nucleus, and then activates the transcription of vascular endothelial growth factor which promotes tumor angiogenesis, leading to a poor chemotherapeutic outcome. 25579062

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Furthermore, our results of VEGF-neutralizing and -rescuing tests showed that metformin markedly abrogated HER2 signaling-induced tumor angiogenesis by inhibiting VEGF secretion. 26625311

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression BEFREE In addition, LRG1 promoted VEGF-A expression in CRC cells and contributed to tumor angiogenesis. 26856989

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Although vascular endothelial growth factor has been established as a critical regulator of tumor angiogenesis, the role of mechanical signaling in the regulation of tumor vasculature or tumor endothelial cell (TEC) function is not known. 25867067

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE In this study, we designed a 5'-triphosphate siRNA targeting VEGF (ppp-VEGF), and showed that ppp-VEGF exerted three distinct antitumor effects: i) inhibition of tumor angiogenesis by silencing VEGF, ii) induction of innate immune responses by activating RIG-I signaling pathway, and thus activate antitumor immunity, iii) induction of apoptosis. 26336994

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 GeneticVariation BEFREE Genetic variation in the VEGF pathway may impact on tumor angiogenesis and, hence, on clinical cancer outcomes. 25707392

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE There is mounting evidence that tumor angiogenesis can be regulated by platelets (Plts), which serve as major sources and delivery vehicles of many proangiogenic cytokines including transforming growth factor-β and vascular endothelial growth factor. 26283102

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Evidence is accumulating that activation of the pancreatic endoplasmic reticulum kinase (PERK) in response to endoplasmic reticulum (ER) stress adapts tumor cells to the tumor microenvironment and enhances tumor angiogenesis by inducing vascular endothelial growth factor A (VEGF-A). 25794107

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE In the tumor microenvironment, VEGF released from cancer cells plays a key role in promoting tumor angiogenesis. 27000664

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE In vitro effects of activin-A on baseline and vascular endothelial growth factor (VEGF)-induced human endothelial cell angiogenesis, signalling and cytokine release were compared with BALF concentrations of these cytokines in vivo.Activin-A expression was significantly elevated in serum, BALF and bronchial tissue of the asthmatics, while expression of its protein receptors was reduced. 26869672

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE The major mediator of tumor angiogenesis is VEGF-A, frequently referred to as VEGF, which activates the VEGF receptor-2. 25560472

2015

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE The vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling cascade plays a critical role in tumor angiogenesis and metastasis and has been correlated with several poorly prognostic cancers such as malignant gliomas. 25353068

2015

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE They can modulate pro-angiogenic signals induced by vascular endothelial growth factor (VEGF) and anti-angiogenic signals induced by thrombospondin-1 (TSP-1), and therefore promote or inhibit tumor angiogenesis. 26144623

2015

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Collectively, we discovered a miR-361-5p/VEGF-dependent regulation that could help to develop new therapeutic modalities not only for ischemia-related diseases but also for tumor angiogenesis. 24865854

2015