Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE When assessed by a priori defined functional pathways, tumor growth factor β (TGFβ) signaling was associated with CRC risk (<i>P</i> ≤ 0.001), with most statistically significant genes being <i>SMAD7 (P<sub>BH</sub></i> = 0.008) and <i>SMAD3 (P<sub>BH</sub></i> = 0.008), and 18 SNPs in the vitamin D receptor (VDR) binding sites (<i>P</i> = 0.036). 31434255

2019

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE In this review, we summarize the available evidences about the role of Smad7 in both sporadic and colitis-associated CRC. 31052449

2019

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE As partial validation of our approach, a known CRC risk variant in SMAD7 (in both the TGF-β and WNT pathways: rs11874392) was associated with CRC risk in our data. 29986644

2018

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE We found that two of the loci most strongly linked with colorectal cancer (CRC) risk, 8q24 (upstream of MYC) and 18q21 (in the intron of SMAD7), as well as 20q13 (in the intron of LAMA5), are tightly associated with the prognosis of rectal cancer patients. 29119627

2018

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Single Nucleotide Polymorphism in SMAD7 and CHI3L1 and Colorectal Cancer Risk. 30498395

2018

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE EGFR, SMAD7, and TGFBR2 are associated with CRC risk in patients with Lynch syndrome. 30275229

2018

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE As regards the polymorphism of SMAD7, we found that CC (wild) genotype has high percentage in controls compared to CRC cases (36.1% vs 15.1%). 28374902

2018

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE These findings delineate a novel mechanism by which Smad7 knockdown promotes CRC cell death. 28300830

2017

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population. 28467803

2017

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE The two stage association studies showed that missense variant rs3764482 (c. 83C>T; p. rs3764482" genes_norm="4092">S28F) in the gene SMAD7 was consistently and significantly associated with CRC risk. 28218435

2017

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Eight miRSNPs (rs1804191, rs397768, rs41116 in APC; rs1137918, s227091, rs4585 in ATM; rs712, rs1137282, rs61764370 in KRAS; rs8674 in PARP1 and rs16950113 in SMAD7) were tested for their association with CRC risk in a case-control study (1111 cases and 1469 healthy controls). 29048575

2017

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE The SMAD7 gene and specifically the allele C could be protective for colorectal cancer. 29084532

2017

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE In conclusion, our data suggest that SMAD7 rs4939827 and CHI3L1 rs4950928 SNPs have no significant association with CRC. 26779637

2016

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE In summary, this large-scale meta-analysis indicated that SMAD7 polymorphisms (rs4464148, rs4939827, and rs12953717) correlate with CRC. 28070019

2016

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE RHOA, SMAD2, SMAD4, SMAD5, SMAD6, BMPR1A, SMAD7 and MYC-, which thereby emerge as candidate genes to play an important role in CRC tumor metastasis. 27662660

2016

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Among the European CRC-susceptibility SNPs, rs4939827 in SMAD7 was associated with a significant decreased risk of Korean CRC (age-/gender-adjusted odds ratio [95% confidence interval]: additive model, 0.67 [95% CI, 0.47-0.95]; dominant model, 0.59 [95% CI, 0.39-0.91]). rs4779584 and rs10795668 were associated with CRC risk in females and males, respectively. 23875689

2015

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Our results, combined with previous studies, suggest that IL10, PSCA, IL1B, and SMAD7 are significantly correlated with CRC susceptibility in the Han Chinese population. 24557062

2015

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE For SMAD7 gene, rs4939827 and rs4464148 are risk factors for CRC among Caucasian whereas rs12953717 could elevate the susceptibility to CRC in both Caucasian and Asian. 26579801

2015

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Intronic polymorphisms of the SMAD7 gene in association with colorectal cancer. 25640388

2015

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE SNP rs7229639 in the SMAD7 gene was found to be associated with CRC risk with an odds ratio (95% confidence interval) associated with the minor allele (A) of 1.22 (1.15-1.29) in the combined analysis of all 11 studies (p = 2.93 × 10(-11) ). 24448986

2014

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE Consistently, knockdown of Smad7 associates with inactivation of eIF2α, lower CDC25A expression and diminished fraction of proliferating cells in human CRC explants, and reduces the number of intestinal tumors in Apc(min/+) mice. 24556688

2014

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE The low expression of IL17A caused by the Smad7 expression in tumor-infiltrating CD4(+) T cells enabled the TNF-α-mediated killing of cancer cells both in vitro and in vivo, thus indicating that the Smad7-mediated plastic effect on T-cell phenotype induces protection against colorectal cancer. 24480808

2014

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Genome-wide association studies (GWAS) in colorectal cancer (CRC) identified five regions near transforming growth factor β-related genes BMP4, GREM1, CDH1, SMAD7 and RPHN2. 24753543

2014

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE The aim of this study was to investigate the influence of a SMAD7 gene polymorphism (rs2337107) on risk of CRC and clinicopathological features in an Iranian population. 24969865

2014

Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Taken together, we propose that the associated CRC risk at 18q21.1 is due to four functional variants that regulate SMAD7 expression and potentially perturb a BMP negative feedback loop in TGFβ/BMP signaling pathways. 25375357

2014