×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
Moreover, coexpression of Snail and ABCB1 was observed in CRC patients.
31774615
2020
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
Overall, our data show that EGCG may be act as a novel chemo-sensitizer, and the GRP78/NF-κB/miR-155-5p/MDR1 pathway plays a vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU.
30741544
2019
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
P-Glycoprotein 1 Affects Chemoactivities of Resveratrol against Human Colorectal Cancer Cells.
31487863
2019
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1 .
30306567
2019
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
GeneticVariation
BEFREE
In this study, a panel of 5 SNPs, namely ABCC2 (-24C > T/rs717620 and c.4544 G > A/rs8187710 ), ABCG2 (c.421 C > A/rs2231142 ), ABCB1 (c.3435 C > T/rs1045642 ) and SLC31A1 (c.-36 + 2451 T > G/rs10981694 ), was evaluated to assess their association with grade 2-3 OXPN in metastatic CRC patients.
30713338
2019
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
AlteredExpression
BEFREE
Further studies on herbal medicines with demonstrated effects against P-gp overexpression will aid in improving the efficacy of chemotherapy in CRC .
30158992
2018
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
AlteredExpression
BEFREE
While expression levels of Nrf2 and ABCB1 (P-gp ) were markedly higher in both mRNA and protein levels in CRC biopsies (p < 0.01), Keap1 expression level was significantly lower in these samples (p < 0.05).
29793178
2018
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
AlteredExpression
BEFREE
Furthermore, studies of colorectal cancer specimens indicated that the expression of miR-26b and Pgp had inverse correlation.
30662808
2018
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
GeneticVariation
BEFREE
Genotyping of ABCB1 variants can help to prevent severe adverse reactions to irinotecan-based treatments in colorectal cancer .
30213564
2018
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
Knockdown of Long Non-Coding RNA XIST Inhibited Doxorubicin Resistance in Colorectal Cancer by Upregulation of miR-124 and Downregulation of SGK1.
30439718
2018
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
However, it is unclear whether similar mechanisms of doxorubicin resistance are involved in colorectal cancer (CRC ).
29701752
2018
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
GeneticVariation
BEFREE
We investigated the consequences of ABCB1 /MDR1 loss-of-function in a common murine model for CAC (AOM/DSS).
28686677
2017
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
Moreover, a significantly positive association between RARγ and MDR1 was demonstrated in CRC tissue microarrays.
28272990
2017
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
AlteredExpression
BEFREE
Visfatin mediates doxorubicin resistance in human colorectal cancer cells via up regulation of multidrug resistance 1 (MDR1 ).
28667355
2017
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
The expressions of MDR-associated protein topoisomerase II (Topo II) and P-glycoprotein (P-gp ) in CRC tissues were detected by immunohistochemistry.
28816939
2017
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer : In vitro and in vivo study.
28302530
2017
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
AlteredExpression
BEFREE
DTA0100 mitotic arrest properties were investigated in two multi-drug resistant cancer cell lines with P-glycoprotein overexpression (colorectal carcinoma and glioblastoma).
28502672
2017
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
GeneticVariation
BEFREE
Association between MDR1 C3435T polymorphism and colorectal cancer risk: A meta-analysis.
29390571
2017
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
The purpose of this present study was to investigate the reversal effect of BU on ABCB1 -mediated multidrug resistance in colorectal cancer .
28624793
2017
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
The expression of cytochrome P450 2C19 (CYP2C19) and ATP-binding cassette, sub-family B member 1 (ABCB1 ) were significantly lower in the EREC group (6/15) compared to the NREC group (9/15) in colorectal cancer with metachronous liver metastasis and with serum CEA >5 ng/ml.
27127120
2016
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
AlteredExpression
BEFREE
In the present study, we showed that PIK3CA and PIK3CB are upregulated in CRC s and positively correlated with MDR-1 , LRP, and GST-π.
26747178
2016
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
AlteredExpression
BEFREE
We previously reported that the Caudal-related homeobox transcription factor CDX2 transcriptionally regulates MDR1 expression in colorectal cancer .
27060927
2016
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
Our results suggest that the ABC transporters P-glycoprotein /multidrug resistance 1 and BRCP, in cooperation with IL-10, are involved in the biological mechanism underlying the protective effect of fiber intake in relation to CRC .
26109419
2015
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
Biomarker
BEFREE
Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer .
25691056
2015
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
Colorectal Carcinoma
0.600
AlteredExpression
BEFREE
Results revealed that the protein and messenger RNA expressions of Beclin1, LC3, mTOR, Raptor, Rictor, and MDR-1 in CRC are significantly higher than in adjacent tissues.
26363527
2015