Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE Moreover, coexpression of Snail and ABCB1 was observed in CRC patients. 31774615

2020
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE Overall, our data show that EGCG may be act as a novel chemo-sensitizer, and the GRP78/NF-κB/miR-155-5p/MDR1 pathway plays a vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU. 30741544

2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE P-Glycoprotein 1 Affects Chemoactivities of Resveratrol against Human Colorectal Cancer Cells. 31487863

2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1. 30306567

2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation BEFREE In this study, a panel of 5 SNPs, namely ABCC2 (-24C > T/rs717620 and c.4544 G > A/rs8187710), ABCG2 (c.421 C > A/rs2231142), ABCB1 (c.3435 C > T/rs1045642) and SLC31A1 (c.-36 + 2451 T > G/rs10981694), was evaluated to assess their association with grade 2-3 OXPN in metastatic CRC patients. 30713338

2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 AlteredExpression BEFREE Further studies on herbal medicines with demonstrated effects against P-gp overexpression will aid in improving the efficacy of chemotherapy in CRC. 30158992

2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 AlteredExpression BEFREE While expression levels of Nrf2 and ABCB1 (P-gp) were markedly higher in both mRNA and protein levels in CRC biopsies (p < 0.01), Keap1 expression level was significantly lower in these samples (p < 0.05). 29793178

2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 AlteredExpression BEFREE Furthermore, studies of colorectal cancer specimens indicated that the expression of miR-26b and Pgp had inverse correlation. 30662808

2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation BEFREE Genotyping of ABCB1 variants can help to prevent severe adverse reactions to irinotecan-based treatments in colorectal cancer. 30213564

2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE Knockdown of Long Non-Coding RNA XIST Inhibited Doxorubicin Resistance in Colorectal Cancer by Upregulation of miR-124 and Downregulation of SGK1. 30439718

2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE However, it is unclear whether similar mechanisms of doxorubicin resistance are involved in colorectal cancer (CRC). 29701752

2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation BEFREE We investigated the consequences of ABCB1/MDR1 loss-of-function in a common murine model for CAC (AOM/DSS). 28686677

2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE Moreover, a significantly positive association between RARγ and MDR1 was demonstrated in CRC tissue microarrays. 28272990

2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 AlteredExpression BEFREE Visfatin mediates doxorubicin resistance in human colorectal cancer cells via up regulation of multidrug resistance 1 (MDR1). 28667355

2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE The expressions of MDR-associated protein topoisomerase II (Topo II) and P-glycoprotein (P-gp) in CRC tissues were detected by immunohistochemistry. 28816939

2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study. 28302530

2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 AlteredExpression BEFREE DTA0100 mitotic arrest properties were investigated in two multi-drug resistant cancer cell lines with P-glycoprotein overexpression (colorectal carcinoma and glioblastoma). 28502672

2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation BEFREE Association between MDR1 C3435T polymorphism and colorectal cancer risk: A meta-analysis. 29390571

2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE The purpose of this present study was to investigate the reversal effect of BU on ABCB1-mediated multidrug resistance in colorectal cancer. 28624793

2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE The expression of cytochrome P450 2C19 (CYP2C19) and ATP-binding cassette, sub-family B member 1 (ABCB1) were significantly lower in the EREC group (6/15) compared to the NREC group (9/15) in colorectal cancer with metachronous liver metastasis and with serum CEA >5 ng/ml. 27127120

2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 AlteredExpression BEFREE In the present study, we showed that PIK3CA and PIK3CB are upregulated in CRCs and positively correlated with MDR-1, LRP, and GST-π. 26747178

2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 AlteredExpression BEFREE We previously reported that the Caudal-related homeobox transcription factor CDX2 transcriptionally regulates MDR1 expression in colorectal cancer. 27060927

2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE Our results suggest that the ABC transporters P-glycoprotein/multidrug resistance 1 and BRCP, in cooperation with IL-10, are involved in the biological mechanism underlying the protective effect of fiber intake in relation to CRC. 26109419

2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker BEFREE Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer. 25691056

2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 AlteredExpression BEFREE Results revealed that the protein and messenger RNA expressions of Beclin1, LC3, mTOR, Raptor, Rictor, and MDR-1 in CRC are significantly higher than in adjacent tissues. 26363527

2015