Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Knockout of fibronectin expression in GBM cell lines inhibited proliferation and migration, increased sensitivity to apoptosis induced by temozolomide in vitro, and markedly suppressed GBM tumor growth and promoted animal survival. 31491450

2019

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Lipid phosphatases SKIP and SHIP2 regulate fibronectin-dependent cell migration in glioblastoma. 30695232

2019

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Western blot analysis, the reverse transcription-quantitative polymerase chain reaction, immunohistochemistry, apoptosis assays and immunofluorescence were employed to examine the effects of tunicamycin on apoptosis, viability, aggressiveness and cell cycle arrest of glioblastoma cells by downregulation of the expression levels of fibronectin and epithelial cadherin. 30127865

2018

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Further, TGF-β induced EDA+FN and EDB+FN in human cerebral microvascular endothelial cells and glioblastoma-derived endothelial cells in a SMAD3- and SMAD4-dependent manner. 29158223

2018

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Tumor-Associated Fibronectin Targeted Liposomal Nanoplatform for Cyclophilin A siRNA Delivery and Targeted Malignant Glioblastoma Therapy. 30386245

2018

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Overexpression of fibronectin is strongly associated with the perivascular regions of glioblastoma multiforme and plays a critical role in migrating and invasive glioma cells. 28675230

2017

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Our results suggest that the fibronectin-adherent population of MCs isolated from peripheral blood can be an effective tool to inhibit GBM growth. 28434806

2017

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Pep-1 was used to overcome the blood-brain tumor barrier (BBTB) and home to glioma cells via interleukin-13 receptor-α2-mediated endocytosis, and CREKA was used to bind to fibrin-fibronectin complexes abundantly expressed in tumor microenvironment for enhanced retention in the GBM. 28933201

2017

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Dexamethasone-Mediated Activation of Fibronectin Matrix Assembly Reduces Dispersal of Primary Human Glioblastoma Cells. 26284619

2015

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Fibronectin expression in glioblastomas promotes cell cohesion, collective invasion of basement membrane in vitro and orthotopic tumor growth in mice. 23912459

2014

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Here, it is demonstrated that the invasive phenotype of glioblastoma multiforme is orchestrated by the transcription factor NF-κB which, via metalloproteinases (MMP), regulates fibronectin processing. 24145173

2013

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE In addition, the expression of integrin αV and its strong ligand FN was prominently increased in glioblastomas developed from mouse intracranial GIC xenografts. 23704872

2013

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251. 10783396

2000

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE The levels of fibronectin (FN) and GFAP mRNA of ten human glioblastoma cell lines, determined by Northern blot hybridization of RNA, were related to other phenotypic characteristics [cell morphology and expression of the genes encoding platelet-derived growth factor (PDGF) receptors]. 1847665

1991