Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE The protein signatures that distinguished Grade II or III from GBM had largely overlapped, and pathway analysis revealed the positive enrichment of extracellular matrix proteins (ECM), MYC pathway, uPAR pathway and G2/M checkpoint genes in GBM. 30401645

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE TAp63 represses transcription of MYC oncogene in glioblastomas; however, its role in another MYC family gene, MYCN, has remained elusive. 31427086

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE The TRIP13/FBXW7/c-MYC pathway might act as a prospective therapeutic target for GBM patients. 31740732

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Mammalian Target of Rapamycin 2 (MTOR2) and C-MYC Modulate Glucosamine-6-Phosphate Synthesis in Glioblastoma (GBM) Cells Through Glutamine: Fructose-6-Phosphate Aminotransferase 1 (GFAT1). 30771196

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE We show that MYC or MYCN amplification in patient-derived glioblastoma stem-like cells (GSCs) generates sensitivity to PARPi via Myc-mediated transcriptional repression of CDK18, while most tumors without amplification are not sensitive. 31266951

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associated with aberrant MYC function in various cancers, including brain tumors such as glioblastoma. 31694585

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Collectively, targeting HELLS may permit the functional disruption of the relatively undruggable MYC and E2F3 transcription factors and serve as a novel therapeutic paradigm for glioblastoma. 30779712

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Correction to: Mammalian Target of Rapamycin 2 (MTOR2) and C-MYC Modulate Glucosamine-6-Phosphate Synthesis in Glioblastoma (GBM) Cells Through Glutamine: Fructose-6-Phosphate Aminotransferase 1 (GFAT1). 31414301

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 GeneticVariation BEFREE Inhibition of repair processes and comparison of the mouse tumors with human medulloblastomas (n = 68) and glioblastomas (n = 32) identified chromothripsis as associated with MYC/MYCN gains and with DNA repair deficiencies, pointing towards therapeutic opportunities to target DNA repair defects in tumors with complex genomic rearrangements. 30420702

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Among astrocytomas, mRNA expression of OCT4, MYC and (less robust) KLF4 increased with malignancy, while in recurrent glioblastomas MYC expression slightly decreased. 27600094

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE We further demonstrate that co-therapy with IRES-J007 and PP242 significantly reduces tumor growth of GBM xenografts in mice and that combined inhibitor treatments markedly reduce the mRNA translational state of cyclin D1 and c-MYC transcripts in these tumors. 27226604

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE The glycolytic dependency of Myc-driven glioblastoma was tested using (13)C metabolic flux analysis, glucose-limiting culture assays, and glycolysis inhibitors, including inhibitors of the NAD(+) salvage enzyme nicotinamide phosphoribosyl-transferase (NAMPT), in MYC and MYCN shRNA knockdown and lentivirus overexpression systems and in patient-derived glioblastoma tumorspheres with and without MYC/MYCN amplification. 27076630

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE This occurs because Omomyc interferes with proper MYC localization and itself associates with the genome, with a preference for sites occupied by MYC This is accompanied by selective repression of master transcription factors for glioblastoma stemlike cell identity such as OLIG2, POU3F2, SOX2, upregulation of effectors of tumour suppression and differentiation such as ID4, MIAT, PTEN, and modulation of the expression of microRNAs that target molecules implicated in glioblastoma growth and invasion such as EGFR and ZEB1. 27852622

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE We also show that genes whose expression in hypoxia is affected by c-MYC inhibition are able to distinguish the Proneural subtype of glioblastoma multiforme, thus potentially providing a molecular signature for this class of tumors that are the least tractable among glioblastomas. 27119353

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Results from both chromatin immune-precipitation (ChIP) and super-shift assays clearly demonstrated the loss of MYC and E-box 3 binding in GBM, suggesting for the first time that a defective MYC and E-box3 binding in GBM is responsible for the differential MYC mediated transcriptional inhibition of MC-let-7a-1~let-7d and potentially other tumor suppressors. 27409345

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Transcription factor analysis suggested that cell death in female patients with GBM is associated with MYC, while that in male patients is associated with TP53 activity. 25490189

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE C-Myc negatively controls the tumor suppressor PTEN by upregulating miR-26a in glioblastoma multiforme cells. 24140063

2013

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Here, we show that both genetic and pharmacologic inhibition of SAPK2/p38 in glioblastoma multiforme cells significantly reduces rapamycin-induced IRES-mediated translation initiation of cyclin D1 and c-MYC, resulting in increased G(1) arrest in vitro and inhibition of tumor growth in xenografts. 21911485

2011

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE We showed that Gas41 is able to bind both n-Myc and c-Myc proteins, and that the levels of expression of Gas41 and Myc proteins were similar to each other in such brain tumors as neuroblastomas and glioblastomas. 22068108

2011

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Three novel MYC-interacting genes (UBE2C, EMP1, and FBXW7) with cancer-related functions were identified as network constituents differentially expressed in gliomas, as was CD151 as a new component of a network that mediates glioblastoma cell invasion. 16204036

2005

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 GeneticVariation BEFREE We now describe the amplification and expression of the cellular oncogene c-myc in double-minute-containing cells from a patient with glioblastoma multiforme, and we have shown that the amplification is associated with rearrangement of the c-myc gene. 3001737

1986