Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Analyses of apoptotic signaling events revealed that pinoresinol enhanced the formation of TRAIL-mediated death-inducing signaling complex (DISC) and complete processing of procaspase-8 within the DISC in glioblastoma cells, in which caspase-8 was inactivated. 31534206

2019

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Here, we show that depletion of eIF5B sensitizes glioblastoma multiforme cells to TRAIL-induced apoptosis by a pathway involving caspases-8, -9, and -7, with no significant effect on cell cycle progression. eIF5B promotes evasion of apoptosis by promoting the translation of several IRES-containing mRNAs, encoding the antiapoptotic proteins XIAP, Bcl-xL, cIAP1, and c-FLIP<sub>S</sub>. 30670698

2019

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Apart from genetic changes in DR4-Ser424, we further classified various cancer cell lines originated from stomach, colon, lung, and glioblastoma according to their sensitivity to and receptor preference upon TRAIL death signaling and generated TRAIL-tolerant persister-derived DLD-1<sup>PER</sup> cells. 30987996

2019

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Our current findings show that these biologic delivery vehicles have high tumor tropism efficacy and expression TRAIL gene under the trigger of TGF-β-secreting GBMs, as well as avoid unspecific TRAIL secretion into normal brain tissue. hAMSC-SBE4-TRAIL inhibited the proliferation and induced apoptosis in experimental GBMs both in vitro and in vivo. 30867058

2019

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival. 31319548

2019

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Taken together, our results identify the novel C27OAs as TRAIL sensitizers targeting the upstream DISC assembly of DR5, and provide a rationale for further development of C27OAs for facilitating TRAIL-based chemotherapy in glioblastoma patients. 30359578

2018

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism. 30385739

2018

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Taken together, this study provides evidence for the further development of metal-based anticancer agents and chemosensitizers of TRAIL for the treatment of human glioblastoma cancer cells. 29963768

2018

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Synergistic effect of TRAIL and irradiation in elimination of glioblastoma stem-like cells. 29777390

2018

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE This combinational therapy through PEI-PLL-transfected mesenchymal stem cells can provide cost-effective, low immunogenic, and tumor-targeted delivery of suicideal genes (HSV-TK and TRAIL) for promising glioblastoma treatment. 30223091

2018

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Altogether, our findings show that H5CmTERT-Ad/TRAIL can promote dispersion of an oncolytic adenovirus through robust induction of apoptosis in a highly TRAIL-resistant glioblastoma. 29362367

2018

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE This work thus demonstrates the ability of oHSV-TRAIL to overcome the therapeutic resistance and recurrence of GBM, and provides a basis for its testing in a GBM clinical trial. 28567859

2017

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE To define the novel pathways that regulate susceptibility to TRAIL in GBM cells, we performed a genome-wide expression profiling of microRNAs in GBM cell lines with the distinct sensitivity to TRAIL-induced apoptosis. 28459998

2017

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE In conclusion, our data demonstrate that miR-133a promotes TRAIL resistance in glioblastoma by suppressing DR5 expression and activating NF-κB signaling. 28918048

2017

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE We designed an adeno-associated virus (AAV) vector for intracranial delivery of secreted, soluble tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) to GBM tumors in mice and combined it with the TRAIL-sensitizing cardiac glycoside, lanatoside C (lan C). 26708508

2016

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE The sensitizing effects of PARP inhibition on TRAIL-mediated apoptosis and potential toxicity were analyzed using viability assays and flow cytometry in established GBM cell lines, low-passage neurospheres and astrocytes in vitro. 25531448

2014

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Therefore, NP-TRAIL represents a targeted anticancer agent with more efficient action for the treatment of GBM and the eradication of GSCs. 23144078

2013

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE In this study, we developed for the first time a novel vector CRAd5/11-D24.TRAIL/arresten by the following strategies: (1) modify CRAd5-D24 with Ad5/11 chimeric fiber to improve its infection efficiency for glioblastoma; and (2) insert two transgene expression cassettes into the E3 region and the region between the fiber and E4, respectively, for an enhanced therapeutic effect. 22136065

2012

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Here we will, after briefly detailing the biology of TRAIL/TRAIL receptor signalling, focus on the promises and pitfalls of recombinant TRAIL as a therapeutic agent alone and in combinatorial therapeutic approaches for GBM. 20102513

2010

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. 20623264

2010

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Our data suggest that therapy with TRAIL, either as monotherapy or in combination with demethylating agents, is not effective in treating glioblastoma because SCGs are not targeted by such treatment. 19214542

2009

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Moreover, shWTE5 significantly enhanced apoptosis induced by chemotherapeutic agents, doxorubicin (DOX) and etoposide (ETP), or by death ligand TRAIL in all of the four solid tumor cells examined (HT-1080, LU99B, TYK and A172). 18292948

2008

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Moreover, lovastatin sensitized glioblastoma cells to TRAIL, suggesting a new strategy to treat glioblastoma. 17928957

2008

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Weak expression of DR5 in primary glioma might limit the therapeutic application of Apo2L/TRAIL in human glioblastoma patients. 17595512

2007