Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Efficient disruption of bcr-abl gene by CRISPR RNA-guided FokI nucleases depresses the oncogenesis of chronic myeloid leukemia cells. 31138265

2019

Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Interestingly, enforced expression of WASP in BCR-ABL1-positive K562 cells increases the susceptibility to apoptosis induced by TRAIL or chemotherapeutic drugs and negatively modulates BCR-ABL1-induced tumorigenesis in vitro and in vivo. 29022901

2017

Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE BCR-ABL governs carcinogenesis through well-organized web of antiapoptotic proteins and over-expressed oncomirs which target death receptors and pro-apoptotic genes. 23229677

2013

Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Moreover, we identified that miR-203 may suppress the tumorigenesis at least in part through negatively regulating its target gene ABL1. 23968727

2013

Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Increasing sophisticated information suggests that cancer cells express constitutively active oncogenic kinases such as breakpoint cluster region- c-abl oncogene 1, non-receptor tyrosine kinase (BCR-ABL1) that promote carcinogenesis independent of extrinsic growth factors. 23575065

2013

Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis. 22231445

2012

Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Moreover, NGAL is required for BCR-ABL-induced tumorigenesis. 21133718

2011

Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Since resistance to apoptosis is an essential step for the tumorigenesis process, we next examined the effect of the MPA-mediated necrotic signal on different tumor cells demonstrating various mechanisms of resistance to apoptosis (Bcl2-, HSP70-, Lyn-, BCR-ABL-overexpressing cells). 19430526

2009

Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Lipocalin 2 is required for BCR-ABL-induced tumorigenesis. 18663364

2008

Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE These findings implicate activation of Ras function as an important component in BCR-ABL-mediated transformation and demonstrate that GRB-2 not only functions in normal development and mitogenesis but also plays a role in oncogenesis. 8402896

1993