Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE Future studies should assess MMP-1 as a prognostic marker for patients with breast cancer and its inhibition as a novel strategy for controlling breast cancer. 30675232

2019

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE Matrix metalloproteinase-1 (MMP-1) is also important in breast cancer carcinogenesis. 31537868

2019

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Meanwhile, high transcription levels of MMP1/3/11/12/13 predicted shorter distant metastasis-free survival, while high levels of MMP1/12 demonstrated worse overall survival in patients with BC. 31452777

2019

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE Moreover, ST08 also showed inhibition on breast cancer cell migration by inhibiting MMP1 (matrix metalloproteinase 1). 31638975

2019

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE Importantly, the distinctive blockades associated with the chemokine CCL5, a prognostic factor for disease progression in breast cancer, along with other low-mass biomarkers of breast cancer (PI3, TIMP1, and MMP1) were identified in the context of the secretome of these three cell types, tracked with time, and used to provide information on the cellular phenotype. 29870666

2018

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 GeneticVariation BEFREE Our findings suggest that the polymorphic genotypes at MMP1 promoter -1607 investigated in the current study, may not play a major role in determining cancer susceptibility to breast cancer in Taiwan. 29695550

2018

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE Overall, the results revealed that in CAFs, MMP-1 synergized with Collagen IV as a key gene in regulating the chemotherapeutic effect of Taxotere on breast tumor cells and served an important role in reducing the efficacy of Taxotere on breast cancer, potentially via the transforming growth factor-β signaling pathway. 30127959

2018

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE Considering the bioactivities exhibited by microalgae, the effect of protein extract of Chlorella minutissimma (CP extract) was investigated on the expression of human matrix metalloproteinases-1 (MMP-1) in the breast cancer cell line MDA-MB231, and that of MMP-2 and -9 in hepatocellular cancer cell line HepG2 at different expression levels. 29633599

2018

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Compounds <b>2</b> and <b>4</b> showed potent inhibitory effects on the expression of MMP1 and MMP2 (matrix metalloproteinases family) in human breast cancer (MCF-7) cells. 30109192

2018

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE An inverse expression pattern was also found between miR-361-5p and FGFR1 or MMP-1 in a cohort of 60 BC tissues. 29132384

2017

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE In this study, we further investigated the functional role of MMP1 and how it is upregulated in multi-drug resistant (MDR) breast cancer cells. 28334049

2017

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Taken together, the expression status of MMP1 is a significant prognostic indicator and a potential drug target for breast cancer. 29207651

2017

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 GeneticVariation BEFREE Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer. 28961241

2017

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 GeneticVariation BEFREE The contribution of MMP1 promoter 1607 genotype to prognosis and subtypes of breast cancer needs further investigation. 27354592

2016

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE NF-κB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro. 26513020

2015

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE We analyzed clinical significance of 21 matrix metalloproteinases on brain metastasis-free survival of breast cancer followed by verification in brain metastatic cell lines and found that only matrix metalloproteinase 1 (MMP1) is significantly correlated with brain metastasis. 25691572

2015

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Tyrosyl phosphorylated PAK1 also stimulates invasion of breast cancer cells in response to PRL and three-dimensional (3D) collagen IV via transcription and secretion of MMP-1 and MMP-3 in a MAPK-dependent manner. 25472536

2015

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE In this study we evaluate the relationship between Pit-1 and two collagenases: matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13), which have been related to metastasis in breast cancer. 25527274

2014

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Microarray results indicate that mRNA expression of MMP-1, -9,-11,-12, and -13 were up-regulated in higher BC grades when compared to normal breast tissues. 24596383

2014

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-кB mediated matrix metalloproteinase-1 gene regulation. 25022892

2014

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker BEFREE The aim of this study was to assess correlation between CTCs and tumor MMP1 in BC. 24972610

2014

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE We further examined PTK7 expression in BC and LN tissue of 128 BC patients by RT-PCR and its correlation with BC related genes like HER2, HER3, PAI1, MMP1, K19, and CD44. 24409301

2014

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 GeneticVariation BEFREE MMP1 [4 single nucleotide polymorphisms (SNPs)] and MMP2 (2 SNPs) were associated with breast cancer overall. 23696797

2013

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE The results indicate that mRNA expressions of MMP-1, -9,-11,-15,-24 and -25 were upregulated in breast cancer tissues when compared to normal breast tissues. 23568046

2013

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 AlteredExpression BEFREE Herein we examined the regulation mechanism of heregulin- β1 (HRG)-induced MMP-1 and -9 expression in breast cancer cell lines. 22627808

2012