Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Bioinformatics analysis revealed that BARD1 may be a predictive biomarker for prognosis of breast cancer. 31808361

2020

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE The BARD1 protein, which heterodimerizes with BRCA1, is encoded by a known breast cancer susceptibility gene. 30925164

2019

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE BARD1-mutated BC index patients showed a significantly younger mean age at first diagnosis (AAD; 42.3 years, range 24-60 years) compared with the overall study sample (48.6 years, range 17-92 years; P = 0.00347). 31036035

2019

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE BRCA1 or BRCA2 mutations were found in 7.3% of the subjects, 6.3% had a mutation in other breast cancer genes (PALB2, CHEK2, ATM, and BARD1), and 1.6% had mutations in genes not associated with breast cancer. 30933323

2019

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE CircRNA_BARD1 (circ_0001098) was up-regulated in breast cancer with the treatment of TCDD and the up-regulation of circRNA_BARD1 could restrain cell proliferation, block cell cycle and promote cell apoptosis. 30521417

2018

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1. 29686231

2018

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE Germline pathogenic variants in BARD1, BRCA1, BRCA2, PALB2, and RAD51D were associated with high risk (odds ratio > 5.0) of TNBC and greater than 20% lifetime risk for overall breast cancer among Caucasians. 30099541

2018

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. 30383767

2018

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Moreover, GUARDIN also sustains breast cancer 1 (BRCA1) stability by acting as an RNA scaffold to facilitate the heterodimerization of BRCA1 and BRCA1-associated RING domain protein 1 (BARD1). 29593331

2018

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE After exclusion of BRCA1, BRCA2, and syndromic breast cancer genes (CDH1, PTEN, and TP53), observed pathogenic variants in 5 of 16 genes were associated with high or moderately increased risks of breast cancer: ATM (OR, 2.78; 95% CI, 2.22-3.62), BARD1 (OR, 2.16; 95% CI, 1.31-3.63), CHEK2 (OR, 1.48; 95% CI, 1.31-1.67), PALB2 (OR, 7.46; 95% CI, 5.12-11.19), and RAD51D (OR, 3.07; 95% CI, 1.21-7.88). 28418444

2017

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE However,other genes, such as ATM, PALB2, BRIP1, CHEK, BARD1, while lower in frequency, may also increase breast cancer risk. 29093764

2017

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE Loss of heterozygosity studies suggest a causative role of the BARD1 mutation in the development of primary peritoneal cancer, but fail to confirm an association between germline ATM mutations and breast cancer development in this family. 28139868

2017

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE For example, several sex-ratio genes were found to interact with brc-1 and brd-1, the orthologs of the human breast cancer genes BRCA1 and BARD1, respectively. 28506208

2017

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE Twenty patients (19%) were identified to carry deleterious mutations, of whom 13 (12%) were in the BRCA1 or BRCA2, 6 (6%) were in five other known breast cancer predisposition genes and 1 patient had a mutation in both BRCA2 and BARD1. 26757417

2016

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE BARD1 is expressed as splice variant isoforms in breast cancer. 27477900

2016

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE BARD1 is a breast cancer tumor suppressor with multiple domains and functions. 26022179

2015

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE A significant proportion of BRCA1 tumours were positive for PARP1 (non-cleaved), and negative for BARD1 and RAD51 compared with sporadic BC. 25690937

2015

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE BRCA1 and BARD1 expressions were performed by immunohistochemistry and immunofluorescence in 103 breast cancer tumors. 26395808

2015

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE The implicated DNA repair genes BARD1 and RAD51 were modulated in human (MDA-MB-231-BR) and murine (4T1-BR) brain-tropic breast cancer cell lines by lentiviral transduction of cDNA or short hairpin RNA (shRNA) coding sequences. 24948741

2014

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE SNP sites rs2229571 and rs1048108 of BARD1 are associated with a lower risk of breast cancer but not rs2070094. 23966609

2013

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Over the past years BARD1 (BRCA1-associated RING domain 1) has been considered as both a BRCA1 (BReast Cancer susceptibility gene 1, early onset) interactor and tumor suppressor gene mutated in breast and ovarian cancers. 24349422

2013

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE BARD1 Cys557Ser was associated with an increased BC risk (P = 0.04, OR = 3.4 [95 % CI 1.2-10.2]) among cases belonging to families with a strong family history of BC. 22544576

2012

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE The breast cancer susceptibility gene BARD1 (BRCA1-associated RING domain protein, MIM# 601593) acts with BRCA1 in DNA double-strand break (DSB) repair and also in apoptosis initiation. 21344236

2012

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE Further analysis of haplotypes at BARD1 also revealed no evidence that additional common genetic variation not captured by Cys557Ser was associated with breast cancer risk. 21393566

2011

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE Lack of association between BARD1 Cys557Ser variant and breast cancer risk: a meta-analysis of 11,870 cases and 7,687 controls. 21809034

2011