Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE B-cell lymphoma-2-associated transcription factor 1 is overexpressed and contributes to sorafenib resistance in hepatocellular carcinoma. 31237058

2019

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE Here, we report that the combination of hepatocyte nuclear factor 1A (HNF1A), HNF4A and forkhead box protein A3 (FOXA3) synergistically reprograms hepatocellular carcinoma (HCC) cells to hepatocyte-like cells (reprogrammed hepatocytes, rHeps). 30560924

2019

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 GeneticVariation BEFREE From the literature, 2 of 146 (1.4%) hepatocellular carcinomas had HNF1A mutations, and both arose in a background of adenomatosis. 30121369

2019

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE Heat Shock Protein 90α-Dependent B-Cell-2-Associated Transcription Factor 1 Promotes Hepatocellular Carcinoma Proliferation by Regulating MYC Proto-Oncogene c-MYC mRNA Stability. 30015413

2019

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE Scientific research over the period of three decades has reported it as an important player in various liver malignancies such as hepatocellular cancers (HCCs), hepatocellular adenoma (HA), and a more specific HNF-1α-inactivated human hepatocellular adenoma (H-HCAs). 31685031

2019

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE Among these lncRNAs, the expression levels of HNF1A-AS1 were notably correlated with HNF1α levels in HCC cells and human HCC tissues. 29466992

2018

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 GeneticVariation BEFREE In this study, the point mutation of HNF1α gene with c.A1532 > T/p.Q511L was identified in an HCC patient by exon-capture high-throughput sequencing. 29101032

2018

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE However, our present data demonstrated that single transduction of HNF4A or HNF1A had only a limited effect on suppression of HCC cell proliferation. 30220099

2018

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. 30155490

2018

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE Our previous studies have demonstrated the therapeutic effects of HNF1α on hepatic fibrosis and hepatocellular carcinoma (HCC) in animals. 28547778

2017

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE Further analyses revealed a key role of ERK leading to increased phosphorylation of p90-ribosomal S6 kinase (RSK) and a concomitant activation of ETS-like transcription factor-1(ELK1) and Death Receptor protein-5 (DR5) in HCC. 29263422

2017

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE The expression in HA was variable and differed between molecular subtypes of this neoplasm: inflammatory and HNF1A mutation-associated type are characterized by overexpression of c-MET to an extent comparable with poorly-differentiated HCC, whereas Wnt/β-catenin dysfunction-associated type lacks overexpression, and the amount of c-MET protein accumulated in its cells is similar to the levels in non-neoplastic tissue and well- to moderately-differentiated HCC. 29256857

2017

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE Thus, we identified a pathway in which TNFα-NF-κB signaling switches off negative regulation by suppressing HNF-1α-mediated expression of miR-194, revealing insight into the mechanisms linking inflammatory pathways, miRNA, and HCC metastasis. 26221053

2015

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE Mutation analysis of HNF1A [encoding hepatocyte nuclear factor 1 (HNF1)α] was performed for L-FABP-negative HCC cases. 25516669

2014

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE Key features include metabolic alterations (induced by defects in HNF1A), oncogene-induced inflammation (activation of JAK-STAT signaling in inflammatory adenomas), and an association between activation of Wnt/β-catenin signaling and progression of HCAs in hepatocellular carcinomas. 23485860

2013

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE HJV promoter analysis revealed potential HNF-1α and snail-binding sites, but functional analysis ruled out that these transcriptional regulators or promoter methylation are the cause of HJV downregulation in HCC. 21863061

2011

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 GeneticVariation BEFREE Biallelic inactivating mutations of HNF1A have been frequently identified in hepatocellular adenomas (HCA), rare benign liver tumors usually developed in women under oral contraceptives, and in rare cases of hepatocellular carcinomas developed in non-cirrhotic liver. 21975049

2011

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE Among these tumors, biallelic inactivating mutations of the hepatocyte nuclear factor 1alpha (HNF1A) transcription factor have been frequently identified and in rare cases of hepatocellular carcinomas developed in noncirrhotic liver. 20041408

2010

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE Re-expression of HNF-1 in HCC cells reinduced MIA2 in HCC cells to similar levels as found in PHH. 17881540

2008

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 GeneticVariation BEFREE The -803 G > A SNP influenced the transcription efficiency in a hepatocarcinoma cell line as well as the binding efficiency of hepatocyte nuclear factor 1 alpha to the motif. 17006670

2007

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE We identified hepatic nuclear factor 1 (HNF1) as an important liver-specific trans-acting element for the human ACAT2 gene using the human hepatocellular carcinoma cell lines HuH7 and HepG2. 15961790

2005

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE Furthermore, among these four transcription factors, HNF-4 alpha and HNF-1 alpha expressions showed synchronism and had a close relation with HCC differentiation. 12967472

2003

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE These results indicate that inactivation of TCF1, whether sporadic or associated with MODY3, is an important genetic event in the occurrence of human liver adenoma, and may be an early step in the development of some HCCs. 12355088

2002

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE These findings show that poor histological differentiation of HCC correlates with decreases in the level and activity of HNF-1 alpha proteins. 9614379

1998

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE The competitive reverse transcriptional polymerase chain reaction was employed to amplify HNF-1 and vHNF-1 mRNA simultaneously and to examine their expression ratio in total RNA extracted from frozen liver tissues of 37 patients with hepatocellular carcinoma, five patients with hepatoblastoma, and 15 non-neoplastic liver tissues. 8912143

1996