Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker BEFREE Conclusion: This study sheds light on the tumor suppressor role of lncRNA PSTAR, a modulator of the p53 pathway, in HCC. 31148184

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker BEFREE Loss of RDM1 enhances hepatocellular carcinoma progression via p53 and Ras/Raf/ERK pathways. 31670863

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation BEFREE Advanced-stage HCC (BCLC B/C) showed higher frequencies of splicing factor 3b subunit 1 (SF3B1) (P = 0.0003), TP53 (P = 0.0006), and RB Transcriptional Corepressor 1 mutations (P = 0.03). 31206197

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression BEFREE In this study, we examined mRNA expression by quantitative real-time PCR (qRT-PCR) of HOXA10 as well as histone deacetylase (HDAC) and protein levels by Western blot of HOXA10, HDAC1, Cyclin D1, proliferating cell nuclear antigen (PCNA), Survivin and p53 acetylation in HCC tissues and cell lines. 31440094

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker BEFREE Furthermore, pharmacological or RNAi inhibition of the mevalonate pathway restricts the development of murine hepatocellular carcinomas driven by p53 loss. 30580964

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker BEFREE Kinases have been targeted for decades with varying results, but the development of therapeutic resistance is a major challenge.<b>Areas covered</b>: The key roles of the RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1, TP53 microRNAs (miRs) as therapeutic targets are discussed and we suggests novel approaches for targeting miRs or their downstream targets to combat HCC. 31657972

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation BEFREE In vitro, Transwell and doxorubicin (DOX)-induced apoptosis assays revealed that GSTM1 showed opposite functions in different HCC cell lines with varied TP53 genotype statuses. 31605953

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker BEFREE LncRNA PLAC2 upregulates p53 to induce hepatocellular carcinoma cell apoptosis. 31233763

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker BEFREE In this study, we report that the haplo-insufficient tumor suppressor ASPP2, a p53 activator, negatively regulates the mevalonate pathway to mediate its inhibitory effect on tumor growth in hepatocellular carcinoma (HCC). 31685796

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression BEFREE Collectively, SLMP53-2 is a new mutp53-targeting agent with promising antitumor activity, particularly against HCC. 31405179

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker BEFREE This study highlights the importance of FAT4 and TP53 in HCC pathogenesis and identifies new genetic variants that may have potentials for development of precise therapy for HCC. 31395065

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker BEFREE Stratifying by the expression of p53 Ser15-P (<i>P</i> = 0.016), but not by p53 (<i>P</i> = 0.301), revealed significantly different survival outcomes in patients with HCC. 30881947

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation BEFREE It was also found that the most common p53 mutation in hepatocellular carcinomas (R249S) was a much better indicator for poor prognosis than TP53 mutations as a whole. 30542790

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression BEFREE ASPP2 enhances chemotherapeutic sensitivity through the down-regulation of XIAP expression in a p53 independent manner in hepatocellular carcinoma. 30528232

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker BEFREE MT1G serves as a tumor suppressor in hepatocellular carcinoma by interacting with p53. 31732712

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression BEFREE The HCC-induced group showed a significant decrease in the body mass and a significant elevation in the liver weight, alpha-fetoprotein (AFP), liver enzymes, hepatic malondialdehyde (MDA), and p53 protein expression levels as well as genetic mutations in intron 5 of p53 gene in the form of Single-Nucleotide Polymorphisms (SNPs) and insertions. 31781479

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation BEFREE TP53 mutations occurred far less frequently in our pediatric HCC cohort than reported in adult cohorts. 30977242

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation BEFREE To test this hypothesis, the HBV integration sites and the common mutations in the TERT promoter and tumor protein P53 (TP53) coding region were analyzed in 101 HBV-related HCC cases using a capture-next-generation sequencing platform. 30070724

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker BEFREE Using flow cytometry to determine cell cycle analysis and determination the possible mechanisms of action for apoptosis revealed that ME-GA arrested the cell cycle at G2/M that lead to inhibition of hepatocellular carcinoma and induced apoptosis via the extrinsic pathway and its ability to increase p53 transactivation. 30973113

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker BEFREE Small molecules that inhibit MDM2-p53 binding show efficacy against p53 wild-type HCC, but most patients have p53-mutant tumors and intrinsic resistance to such MDM2 inhibitors. 31181320

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker BEFREE Taken together, through the sequestration of IRF2, MVP promotes an HDM2-dependent loss of p53 that promotes HCC development. 31758709

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 PosttranslationalModification BEFREE Co-treatment with SB203580, the p38MAPK inhibitor, prevented pro-apoptotic effect of SAC by altering p53 phosphorylation and death inducing signaling complex conformation in HepG2 and induced HCC. 31067004

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation BEFREE TP53 mutation resulted in the downregulation of the immune response in HCC. 30885723

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression BEFREE Solasonine-induced apoptosis and cell death of HCC cell lines either expressing p53 (HepG2) or not (Hep3b), indicating that apoptotic activities of solasonine can be mediated not only through p53-dependent but also p53-independent pathways. 30628118

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression BEFREE SOX30 regulated HCC progression through aberrant activation of p53 by directly binding to its promoter. 30312695

2019