Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET Finally, bisulfite-sequencing analysis revealed that quetiapine decreased the DNA methylation level of the promoter region of SLC6A4, where hypermethylation with bipolar disorder and hypomethylation with mood stabilizers have been reported. 25194461

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET Abnormal expression and genetic polymorphism of SLC6A3 and SLC6A4 genes may increase the risk of developing mental illness, such as schizophrenia, bipolar disorder, ADHD, and aggressive behavior in Alzheimer disease, etc. 25019689

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET We also found gender-specific interaction between 5-HTTLPR and DRD2 Taq-IA polymorphisms in patients with bipolar disorder. 24229495

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET 5-HTTLPR modulated the relationship between early life stress and the core features of bipolar illness. 25219494

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET However, we found that CpG sites of SLC6A4, which were hypermethylated in patients with bipolar disorder, were hypomethylated in the neuroblastoma cells treated with mood stabilizers. 23931339

2013

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker CTD_human The 5-HTTLPR polymorphism could be a useful contributor, among other clinical variables, to predict the risk for manic switches when a patient with bipolar disorder is treated with antidepressant drugs. 16395126

2006

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker CTD_human Relative to the comparison subjects, subjects with bipolar disorder without panic disorder, but not those with comorbid bipolar disorder and panic disorder, showed significantly higher frequencies of the COMT Met158 and the short 5-HTTLPR alleles and genotypes. 11772685

2002