Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.440 Biomarker PSYGENET These combined data support a physical interaction between PS-1 and MAO-A that could influence MAO-A activity and contribute to the monoaminergic disruptions common to disorders as seemingly diverse as depression and AD. 22045496

2012

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.440 Biomarker PSYGENET Alzheimer disease-related presenilin-1 variants exert distinct effects on monoamine oxidase-A activity in vitro. 21373759

2011

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.440 Biomarker PSYGENET For previously investigated candidate genes, some support (at a nominal significance level of 0.05/0.01) was found for association between NOS1 and personality traits (especially extraversion), PSEN1 and depression/neuroticism, and GRIK3 and depression. 20052609

2010

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.440 Biomarker PSYGENET Female preclinical presenilin-1 mutation carriers unaware of their genetic status have higher levels of depression than their non-mutation carrying kin. 14966176

2004

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.440 Biomarker PSYGENET APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. 11567612

2001