|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our previous data suggested that three single-nucleotide polymorphisms (SNPs), rs1048661, rs3825942, and rs2165241, of the lysyl oxidase-like 1 gene (<i>LOXL1</i>) are significantly associated with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG).
|
31192002 |
2019 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
We aimed to investigate the relationship between <i>LOXL1</i> SNPs (rs1048661, rs3825942) and XFS and/or XFG in a cohort of Iranian subjects.
|
31850260 |
2019 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma did not show any genetic association with either single-nucleotide polymorphism rs1048661 or rs3825942.
|
30189755 |
2019 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
This is the first study associating two SNPs of LOXL1 (rs3825942 and rs2165241) and XFS/XFG in a Spanish population, confirming findings in patients from Europe.
|
24892565 |
2016 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis indicates that rs1048661 ("G" alleles) had weak association with XFG/XFS; rs3825942 ("G" alleles) had strongly association with XFG/XFS; and rs2165241("T" alleles) had significant risk with XFG/XFS in some ethnicity.
|
25304275 |
2016 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
The haplotype frequencies of SNPs rs16958477, rs1048661, rs3825</span>942 and rs2165241 and their association with XFG indicated that the CGGT haplotype, containing all four risk alleles, and the AGGT haplotype, which carries the protective allele of rs16958477 and three risk alleles of the other three SNPs, were significantly associated with XFG (p = 4.5×10(-6), and p = 8.8×10(-6)), conferring more than 2-fold increased disease susceptibility.
|
26319397 |
2015 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Compared with the CT group, subgroup analysis showed that the CRVO EX+ group had significant differences in the allelic and genotypic frequencies of rs1048661 (p = 0.0006447 and p = 0.0001392, respectively) and had borderline differences in the allelic and genotypic frequencies of rs3825942 (p = 0.03403 and p = 0.07341, respectively), while the CRVO EX- group did not (p = 0.1324-0.6306).
|
25130441 |
2015 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Carriers of rs3825942 AA or rs2165241 CC also had significantly less PEXS/PEXG susceptibility than did the non-carriers.
|
24603551 |
2014 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the Thessaloniki Eye Study, the G153D SNP of LOXL1 gene was strongly associated with both PEX and PEXG, whereas the R141L was not associated.
|
24917141 |
2014 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three SNPs of LOXL1 (rs1048661, rs3825942, and 2,165,241) are highly associated with XFS in a Korean population.
|
23441117 |
2013 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
None of the patients with XFS or XFG had the A allele of rs3825942, whereas 16% of the control subjects had that variant (OR=0.025, 95% CI: 0.003-0.188, p=3.69×10(-9)).
|
23378724 |
2013 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
The allele G of G153D showed a significant association with PEXG (OR=3.74, 95% CI=1.670-8.387, p=0.001).
|
23869164 |
2013 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association of XFS and XFG with G153D appeared to be less powerful in this population (XFS: odds ratio [OR]=2.162, p=0.039, XFG: OR=2.794, p=0.002) compared to other populations, and for R141L, the association was proven only with XFG (OR=3.592, p<0.001).
|
23687437 |
2013 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two non-synonymous single-nucleotide polymorphisms of LOXL1, R141L (rs1048661) and G153D (rs3825942), have been reported to significantly increase susceptibility to exfoliation glaucoma (XFG).
|
22328822 |
2012 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
A significant association was found for the G allele of rs1048661 and rs3825942 in PEXG patients of Pakistani origin.
|
22605916 |
2012 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two non-synonymous single-nucleotide polymorphisms of LOXL1, R141L (rs1048661) and G153D (rs3825942), have been reported to significantly increase susceptibility to exfoliation glaucoma (XFG).
|
22328822 |
2012 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
The G allele of rs3825942 was found in a higher frequency in XFS/XFG than in controls (100% vs 95% respectively, p = 0.0019).
|
21970694 |
2012 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Allelic and genotypic frequencies of three LOXL1 variants (rs1048661, rs3825942, and rs2165241) were determined for 78 consecutive Japanese patients with BRVO (11 patients with exfoliation syndrome [EX+], 67 patients without exfoliation syndrome [EX-]), and 158 patients with cataract without EX (CT) as controls.
|
22194657 |
2011 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
The AA genotype of G153D confers XFS risk in this population, as opposed to the GG genotype described in all other populations, suggesting that unidentified genetic or environmental factors independent of these LOXL1 SNPs may influence phenotypic expression of the syndrome.
|
21320968 |
2011 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
The haplotypes G-G for the SNPs rs1048661and rs3825942, G-T for the SNPs rs1048661 and rs2165241, and SNPs rs3825942 and rs2165241 were found to be significantly associated with XFS/G.
|
21738402 |
2011 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
The significant association with PEX was found for the G allele of rs3825942 (p = 0.0047) and for the T allele of rs216541 (p = 0.021).
|
21272281 |
2011 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
The frequency of G allele in R141L and G153D SNPs of the LOXL1 gene did not differ between XFS/XFG patients with and without CVD, but its frequency was different in XFS/XFG and ischemic stroke.
|
20436359 |
2011 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Results show that, controlling for all other variables, mean TAS value (p<0.0001) and the mutation G/G in rs3825942 (p=0.041) are significant risk factors for PEG.
|
22065931 |
2011 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms in LOXL1 (rs1048661, rs3825942, and rs2165241) have been linked to exfoliation syndrome and exfoliation glaucoma, conditions that have shown association with AD.
|
21559813 |
2011 |
|
rs3825942
|
|
Exfoliation Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
To date, the G allele of the major susceptibility variant rs3825942 has consistently been shown in multiple populations to increase the risk of XFG.
|
20431720 |
2010 |