rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Polymorphisms of inosine triphosphate pyrophosphatase (rs1127354 and rs6051702) and interferon lambda 4 (IFLN4) (rs12979860) are indicators of anemia and/or sustained virological response (SVR) in patients with chronic hepatitis C on ribavirin/interferon.
|
31359493 |
2020 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A comparative study of various methods for detection of IL28B rs12979860 in chronic hepatitis C.
|
28281380 |
2017 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Impact of IFNL4 rs12979860 and rs8099917 polymorphisms on response to Peg-Interferon-α and Ribavirin in patients with congenital bleeding disorder and chronic hepatitis C.
|
27735085 |
2017 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A significant increase was observed in the frequencies of unfavorable rs12979860 genotypes/CT + TT in the chronic hepatitis C (CHC) and LTC groups.
|
28214926 |
2017 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The interdependence and roles of T cell-mediated immune responses and IL28B rs12979860 single-nucleotide polymorphism genotype as predictors of virological response to anti-HCV treatment in patients with chronic hepatitis C were evaluated using nonparametric tests.
|
28440692 |
2017 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
IL28B SNP rs12979860 is the Critical Predictor for Sustained Viral Response in Chinese Children Aged 1 to 6 Years with Chronic Hepatitis C.
|
27877087 |
2016 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels.
|
27870883 |
2016 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of the study was to evaluate the association between three most widely studied IL28B gene polymorphisms and the response to antiviral treatment of chronic hepatitis C. We performed the genotyping of the three IL28B gene polymorphisms: rs12979860, rs8099917, and rs12980275 in 72 Caucasian patients with chronic hepatitis C, previously treated with the combination therapy of pegylated interferon alpha (PEGIFN α) and ribavirin (RBV).
|
26614853 |
2015 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
IL28B polymorphism (rs12979860) associated with clearance of HCV infection in Poland: systematic review of its prevalence in chronic hepatitis C patients and general population frequency.
|
25712648 |
2015 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Duplex High-Resolution Melting Assay for the Simultaneous Genotyping of IL28B rs12979860 and PNPLA3 rs738409 Polymorphisms in Chronic Hepatitis C Patients.
|
26389885 |
2015 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
This finding adds evidence that genotyping for the IL-28B rs12979860 SNP can be a good parameter for the prediction of treatment success in patients with chronic hepatitis C before initiation of antiviral therapy in Morocco.
|
25958342 |
2015 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the relationship between IL28B rs12979860 genotype, the level of TNFα activation and the degree of IR in patients with chronic hepatitis C. One hundred and thirty-three nondiabetic genotype 1 HCV-infected patients with biopsy proven noncirrhotic hepatitis C were investigated for IR (using HOMA index), IL28B rs12979860 genotype and fasting circulating levels of soluble receptor 1 of TNFα (sTNFR1) and adipokines: leptin, adiponectin and IL-6.
|
25818002 |
2015 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although the single-nucleotide polymorphism (SNP) rs12979860 in the IL28B gene is a better predictor of sustained virological response to treatment of chronic hepatitis C (CHC) than other baseline factors, some CHC patients with the favorable C allele cannot achieve a sustained virological response when treated with peginterferon plus ribavirin.
|
25687192 |
2015 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped 544 chronic hepatitis C (CHC) patients, 78 spontaneous hepatitis C clearance (SHC) patients and 215 healthy controls for CD24 gene variants at positions -P534, P170, P1527 and IFNL3 rs12979860 by pyrosequencing.
|
25872416 |
2015 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The IL28B genotype in rs12979860 predicts success of peginterferon/ribavirin (PEG/RBV) therapy in patients with chronic hepatitis C (CHC).
|
24205831 |
2014 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies revealed the rs12979860 single nucleotide polymorphism (SNP) of the IL28B gene (CC genotype) to be the strongest pre-therapeutic predictor of therapy response to interferon alpha in patients with chronic hepatitis C infection.
|
25389973 |
2014 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
To assess the role of the ss469415590 variant, compared with the known IL28B polymorphisms (rs8099917, rs12979860 and rs12980275) for predicting virological response to therapy in chronic hepatitis C, and its association with the CXCL10 chemokine serum levels - a surrogate marker of interferon-stimulated genes activation.
|
24308755 |
2014 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent studies in chronic hepatitis C patients have shown that rs368234815 polymorphism nearby IL28B is a better predictor of response to antiviral treatment with pegylated interferon and ribavirin than IL28B polymorphisms (rs12979860 and rs8099917).
|
25130512 |
2014 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
To determine, in a cohort of Spanish patients with chronic hepatitis C treated with peginterferon plus ribavirin (P+R), whether insulin resistance predicts SVR independently of interleukin-28B rs12979860 polymorphism.
|
23121166 |
2013 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C.
|
23220171 |
2013 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients with advanced liver disease carried the rs12979860-T/T genotype more frequently than patients with mild chronic hepatitis C (OR = 1.89; 95% CI, 0.99-3.61; p = 0.0532) and this risk was even more pronounced when we compared them with healthy controls (OR = 4.27; 95% CI, 2.08-8.76; p = 0.0005).
|
23358556 |
2013 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the IL28B gene polymorphism (rs12979860) and virological response in chronic hepatitis C patients.
|
23440114 |
2013 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The mechanism explaining the strong association between IL28B rs12979860 polymorphisms and treatment outcome in chronic hepatitis C remains unclear.
|
22294646 |
2012 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Frequency of IL28B rs12979860 single-nucleotide polymorphism alleles in newborn infants and in patients with chronic hepatitis C in Morocco.
|
22509814 |
2012 |
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in IL28B and serum levels of interferon γ inducible protein 10 (IP-10) predict outcomes of antiviral therapy in patients with chronic hepatitis C. We associated IL28B SNPs rs12979860 and rs8099917, along with serum levels of IP-10, with outcomes of patients with acute hepatitis C (AHC).
|
22192885 |
2012 |