Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Although pharmacological blockade of CB1R has been effective for the treatment of obesity and tobacco addiction, precise distribution of CB1R within the brain and potential changes by obesity or nicotine exposure have not been thoroughly addressed. 31634502 2020
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Cannabinoid receptor-1 (CB1) represents a potential drug target against conditions that include obesity and substance abuse. 31608546 2020
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Consideration of both biological and cultural evolution justifies the design of improved pharmacological treatments for obesity and Type 2 diabetes (T2D) that focus on peripheral CB1R antagonism. 31156558 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE These results indicate that lacking both CB1R and CB2R protected mice from diet-induced obesity, possibly through the prominent role of CB1R in obesity or through an interactive effect of both receptors. 30699233 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Thus, targeting EC receptors, especially CB1R, may provide a potential therapeutic strategy against obesity and insulin resistance. 31035653 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Significant progress was made with the discovery of rimonabant, a selective CB1 receptor (CB1R) antagonist (also an inverse agonist), as a promising therapeutic for SUDs and obesity. 31549358 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Small molecules targeting peripheral CB1 receptors have therapeutic potential in a variety of disorders including obesity-related, hormonal, and metabolic abnormalities, while avoiding the psychoactive effects in the central nervous system. 31433190 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE The overactivity of cannabinoid 1 receptor (CB1R) is associated with obesity and type 2 diabetes. 30566396 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Endocannabinoid is identified as the emerging target for the treatment of obesity as Cannabinoid 1 (CB1) receptor over-activation resulted in abdominal obesity. 30908997 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE A large body of evidence in both animal and human studies suggests that CB1R antagonism is highly effective for the treatment of obesity, metabolic disorders and drug addiction. 31284863 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Antagonists of peripheral type 1 cannabinoid receptors (CB1) may have utility in the treatment of obesity, liver disease, metabolic syndrome and dyslipidemias. 30077609 2018
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE To analyze the metabolic parameters and adipose tissue inflammation via NLRP3 inflammasome following chronic treatment of mouse models of obesity with AJ5018 as the peripherally restricted cannabinoid 1 receptor (CB1R) antagonist. 29740969 2018
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 AlteredExpression disease BEFREE In pharmacological evaluation, the synthesized compounds (23, 25, 27 and 34) showed significant decrease in food intake suggesting their potential application in the management of obesity through CB1 receptor antagonist activity. 29374224 2018
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Cannabinoid receptor gene (CNR1) has been a drug target for the treatment of obesity. 29909009 2018
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 AlteredExpression disease BEFREE Obesity is associated with upregulation of the endocannabinoid system, and blocking the cannabinoid type 1 receptor (CB1R) has been shown to cause weight loss and to decrease cardiometabolic risk factors. 29650773 2018
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Previous studies have shown that the CB1 receptor antagonist reverses steatohepatitis and its related features of metabolic syndrome, such as obesity and type 2 diabetes. 30365523 2018
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Pain, movement disorders, epilepsy, obesity are all potential therapeutic targets for CB1R allosteric modulation. 29355038 2018
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 AlteredExpression disease BEFREE CNR1 is highly expressed in the central nervous system and has been a drug target for the treatment of obesity. 27858284 2017
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE In this work, adipocyte-specific inducible deletion of the CB1 gene (Ati-CB1-KO) was sufficient to protect adult mice from diet-induced obesity and associated metabolic alterations and to reverse the phenotype in already obese mice. 29035280 2017
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE We first explored the effect of rimonabant, a selective CB1R antagonist/inverse agonist, on some metabolic parameters in high fat-diet (HFD)-induced obesity in mice. 28492810 2017
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE All classical CB1R blockers were centrally acting appetite suppressants and decreased body weight and food intake in an obesity-dependent manner, with only slight effects on metabolic syndrome markers. 28666894 2017
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Given CB1 receptors remain as potential pharmacological targets to fight against obesity and T2D, we wanted to explore the metabolic impact of this compound in an animal model of obesity and pre-diabetes as well as the lack of relevant actions in related central processes such as anxiety. 28638091 2017
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Thus, the current study indicates that TXX-522 is a novel and potent peripherally acting selective CB1R antagonist with the potential to control obesity and related metabolic disorders. 29051736 2017
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE In light of recent advances and complexity in the field, we review cannabinoid-based therapeutic strategies for the treatment of obesity and how peripheral restriction of CB1R antagonists may provide a different mechanism of weight loss without the central adverse effects. 28579186 2017
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE The present study aimed to investigate the allelic distribution of polymorphism (G1359A) of the CB1 receptor gene in a geographical area of Spain (Community of Castilla y Leon) and to evaluate the influence of this polymorphism on obesity anthropometric parameters and cardiovascular risk factors in the fasted state in obese patients. 25682784 2016