Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 Biomarker disease BEFREE To study the influence of obesity, mice were challenged with high-fat diet for 22 wk, and LPL was studied after an overnight fast compared with fasted mice given food for 3 h. High-fat diet caused blunting of the normal adaptation of LPL activity to feeding/fasting in adipose tissue, but in kidneys this adaptation was lost only in male mice. 30698048 2019
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 AlteredExpression disease BEFREE We retrospectively reviewed a total of 100 obese patients who were treated for obesity and had preheparin LPL levels measured before and 12 months after LSG or after 12 months of nonsurgical treatment. 31167211 2019
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 GeneticVariation disease BEFREE Among genetic factors that contributed to incidence of metabolic syndrome, Polymorphisms of Lipoprotein lipase (LPL) are major candidates especially because of their effect on obesity and dyslipidemia. 31034941 2019
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 GeneticVariation disease BEFREE RETRACTED: Association between peroxisome proliferator-activated receptor, UCP3 and lipoprotein lipase gene polymorphisms and obesity in Chinese adolescents. 26483159 2017
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 AlteredExpression disease BEFREE Lipoprotein lipase (LPL) activity is considered the rate-limiting step of very-low-density-lipoprotein triglycerides (VLDL-TG) tissue storage, and has been suggested to relate to the development of obesity as well as insulin resistance and type 2 diabetes. 27898284 2017
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 Biomarker disease BEFREE The human lipoprotein lipase (LPL) is a therapeutic target for obesity, and inhibition of LPL with the approved small molecule agent orlistat has been widely used in clinic to treat obesity-related health problems such as diabetes and cardiovascular diseases. 27097985 2017
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 Therapeutic disease RGD Anti-obesity effects of tea from Mangifera indica L. leaves of the Ubá variety in high-fat diet-induced obese rats. 28514832 2017
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 Therapeutic disease RGD Ubá mango juices intake decreases adiposity and inflammation in high-fat diet-induced obese Wistar rats. 27160499 2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 GeneticVariation disease BEFREE Obese subjects had a significantly (P<0.05) higher level of triglyceride (TG), blood pressure, waist-circumference and fasting-blood-glucose, and lower level of HDL-C. LPL and CETP polymorphisms were not associated with obesity in our population. 25579610 2015
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 Biomarker disease BEFREE Rather, there was selective induction of PPARγ-regulated genes such as adiponectin in the adipose of the Adipoq-LPL mice, suggesting that increasing adipose tissue LPL improves glucose metabolism in diet-induced obesity by improving the adipose tissue phenotype. 25784555 2015
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 GeneticVariation disease BEFREE Dietary PUFA modulated the association of LPL rs320 with obesity traits in two independent populations. 25156894 2014
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 AlteredExpression disease BEFREE Pre-existing maternal obesity and GDM are associated with decreased expression in genes involved in fatty acid uptake and intracellular transport (LPL, FATP2, FATP6, FABPpm and ASCL1), triacylglyceride (TAG) biosynthesis (MGAT1,7 MGAT2 and DGAT1), lipogenesis (FASN) and lipolysis (PNPLA2, HSL and MGLL). 24262292 2014
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 GeneticVariation disease BEFREE Mice with neuron-specific deletion of LPL have increases in food intake that lead to obesity, and then reductions in energy expenditure that further contribute to and sustain the phenotype. 22540257 2012
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 Biomarker disease BEFREE Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and is associated with obesity, dyslipidemias, hypertension (HTN) and type 2 diabetes mellitus (T2DM). 23089926 2012
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 AlteredExpression disease BEFREE Overweight/obese women presented lower LPL activity (P=0.022) and higher circulating TNF-α (P=0.020) than controls. 23036713 2012
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 Biomarker disease BEFREE Lipolytic activities in AT are differently altered in obesity and Type 2 diabetes being HSL alteration associated with both insulin-resistant conditions and LPL with diabetes per se. 20926921 2011
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 GeneticVariation disease BEFREE In conclusion, the LPL gene +495T > G and PvuII T > C polymorphisms may modulate the magnitude of dyslipidemia in Chinese early-onset obesity. 21431783 2011
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 GeneticVariation disease BEFREE In summary, we identified significant interactions for APOA5 S19W and LPL m107 for obesity in Caribbean Hispanics. 19629056 2010
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 GeneticVariation disease BEFREE No significant differences were found between the non-deficient LPL cases and the controls in terms of obesity, diabetes, alcohol consumption, drug therapy, gender distribution, evidence of fasting chylomicronaemia, lipid levels, LPL activity and mass, hepatic lipase activity, CII and CIII mass or apo E polymorphisms. 19534808 2009
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 Biomarker disease BEFREE In fact, studies with genetically engineered mice have revealed that the activity of lipoprotein lipase (LPL) is a major determinant for the development of obesity. 19168150 2009
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 AlteredExpression disease BEFREE Overall, LPL is a fascinating enzyme that contributes in a pronounced way to normal lipoprotein metabolism, tissue-specific substrate delivery and utilization, and the many aspects of obesity and other metabolic disorders that relate to energy balance, insulin action, and body weight regulation. 19318514 2009
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 Biomarker disease BEFREE Genetic association study of selected candidate genes (ApoB, LPL, Leptin) and telomere length in obese and hypertensive individuals. 19772655 2009
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 GeneticVariation disease BEFREE Two statistical methods were performed to test the effect of T+495G polymorphism of LPL gene on the relation between central obesity and lipid levels: one was the generalized estimating equation model for all twin pairs and the other was co-twin matched case-control analysis in 82 central obesity discordant monozygotic twin pairs. 18693040 2008
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 Biomarker disease CTD_human Variations in DNA elucidate molecular networks that cause disease. 18344982 2008
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.600 GeneticVariation disease BEFREE Assuming that the variants in the promoter of the LPL gene may be associated with changes in lipid metabolism leading to obesity and type 2 diabetes, we examined the role of promoter variants (-T93G and -G53C) in the LPL gene in an urban South Indian population. 17299379 2007