|
rs4311
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs1799752
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We measured ACE-2 activity by fluorogenic peptide substrate assay in mid-frontal cortex (Brodmann area 9) in a cohort of AD (n = 90) and age-matched non-demented controls (n = 59) for which we have previous data on ACE-1 activity, amyloid β (Aβ) level and tau pathology, as well as known ACE1 (rs1799752) indel polymorphism, apolipoprotein E (APOE) genotype, and cerebral amyloid angiopathy severity scores.
|
27884212 |
2016 |
|
rs1799752
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study is aimed to clarify the association between ACE insertion (I)/deletion (D) polymorphism (rs1799752) and AD.
|
25596842 |
2015 |
|
rs1799752
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In a case-control study including 376 late-onset AD patients and 444 control subjects, we showed a statistically significant effect on the risk of AD of tw</span>o variants (rs4343 and rs1799752) and of the haplotype ATI (rs4343/rs4291/rs1799752) in subjects aged 73 years and above.
|
19539712 |
2009 |
|
rs4343
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In a case-control study including 376 late-onset AD patients and 444 control subjects, we showed a statistically significant effect on the risk of AD of two variants (rs4343 and rs1799752) and of the haplotype ATI (rs4343/rs4291/rs1799752) in subjects aged 73 years and above.
|
19539712 |
2009 |
|
rs4343
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Other variants, such as SNPs rs4291A>T located -240bp from the initiation codon, and rs4343G>A encoding a silent mutation in exon 16, were inconsistently associated with the risk of AD.
|
19539712 |
2009 |
|
rs4343
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The purpose of this study was to examine the impact of two polymorphisms (rs4291A>T and rs4343G>A) in the ACE gene on the risk of Alzheimer's disease (AD), using a population-based cohort of 9294 subjects selected from the electoral rolls of three French cities (the Three-City Study).
|
18431000 |
2008 |
|
rs4343
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These results suggest that a variant in close proximity to rs4343 and rs4351 modulates susceptibility to AD in this community.
|
16642441 |
2006 |
|
rs4291
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Other variants, such as SNPs rs4291A>T located -240bp from the initiation codon, and rs4343G>A encoding a silent mutation in exon 16, were inconsistently associated with the risk of AD.
|
19539712 |
2009 |
|
rs4291
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After adjustment for confounding variables, the risk of developing AD was similar whatever the genotype (rs4291 AT vs TT: OR=0.90, p=0.65; AA vs TT: OR=1.05, p= 0.84; rs4343 GA vs GG: OR=1.15, p= 0.48; AA vs GG: OR=1.25, p= 0.37).
|
18431000 |
2008 |
|
rs4291
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The purpose of this study was to examine the impact of two polymorphisms (rs4291A>T and rs4343G>A) in the ACE gene on the risk of Alzheimer's disease (AD), using a population-based cohort of 9294 subjects selected from the electoral rolls of three French cities (the Three-City Study).
|
18431000 |
2008 |
|
rs143830698
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
rs769397961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
rs776943620
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
rs4351
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that a variant in close proximity to rs4343 and rs4351 modulates susceptibility to AD in this community.
|
16642441 |
2006 |