|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The dominant model of SMAD7 rs12953717 (CT + TT genotypes) significantly increased CRC risk (HR=2.17, 95% CI=1.12-4.16) when compared to the wild-type CC genotype.
|
30275229 |
2018 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For SNPs on 18q21 (rs12953717 and rs4464148) and 20q13 (rs4925386), alleles that correlate with higher risk for the development of CRC are associated with shorter disease free survival (DFS).
|
29119627 |
2018 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Micro RNA-375 and rs4939827 SNP in SMAD7 could be considered as potential markers for detecting and early diagnosing CRC patients.
|
28374902 |
2018 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A decreased risk for CRC cancer was observed for the CC compared to the TT genotype (OR = 0.65 and 95% CI = 0.51-0.81) of the rs4939827 SNP Also, we could show an association between the Mediterranean diet pattern (protective factor) and rs4939827.
|
29084532 |
2017 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the end, we identified the T allele of rs4939827 to be significantly related with an increase CRC risk (P=2.22E-05, OR=1.14, 95% CI 1.07-1.21) in Chinese population.
|
28467803 |
2017 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Subgroup analysis according to ethnicity showed rs4464148 and rs12953717 were associated with the risk of CRC in bo</span>th Caucasians and Asians, whereas rs4939827 was a risk polymorphism for CRC specifically in Caucasians.
|
28070019 |
2016 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, our data suggest that SMAD7 rs4939827 and CHI3L1 rs4950928 SNPs have no significant association with CRC.
|
26779637 |
2016 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Subgroup analysis according to ethnicity showed rs4464148 and rs12953717 were associated with the risk of CRC in both Caucasians and Asians, whereas rs4939827 was a risk polymorphism for CRC specifically in Caucasians.
|
28070019 |
2016 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We confirmed the association of CRC risk with four SNPs, with odds ratio (OR) higher than previously reported: rs16892766 on 8q23.3 (OR: 1.88, 95% confidence interval (CI): 1.30-2.72; P=0.0007); rs4779584 on 15q13.3 (OR: 1.42, CI: 1.11-1.83; P=0.0061) and rs4939827 and rs58920878/Novel 1 on 18q21.1 (OR: 1.49, CI: 1.13-1.98; P=0.007 and OR: 1.49, CI: 1.14-1.95; P=0.0035).
|
25873010 |
2016 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
On the other hand, rs12953717 T allele showed a statistically significant association with CRC risk (adjusted OR=1.339, 95% CI: 1.017-1.764, p=0.037).
|
25640388 |
2015 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For SMAD7 gene, rs4939827 and rs4464148 are risk factors for CRC among Caucasian whereas rs12953717 could elevate the susceptibility to CRC in both Caucasian and Asian.
|
26579801 |
2015 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Based on genome-wide association studies (GWAS) a linkage between several variants such as single nucleotide polymorphisms (SNPs) in intron 3 of SMAD7 (mothers against decapentaplegic homolog7) were, rs12953717, rs4464148 and rs4939827 has been noted for susceptibility to colorectal cancer (CRC).
|
25640388 |
2015 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the European CRC-susceptibility SNPs, rs4939827 in SMAD7 was associated with a significant decreased risk of Korean CRC (age-/gender-adjusted odds ratio [95% confidence interval]: additive model, 0.67 [95% CI, 0.47-0.95]; dominant model, 0.59 [95% CI, 0.39-0.91]). rs4779584 and rs10795668 were associated with CRC risk in females and males, respectively.
|
23875689 |
2015 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Furthermore, the A allele of rs7014346, the A allele of rs10505477, and the T allele of rs4939827 were significantly related with an elevated risk of CRC only among Caucasian.Our study suggested that for CASC8 gene, SNP of rs7837328 and rs6983267 are risk factors for CRC among both Caucasian and Asian whereas rs7014346 and rs10505477 are risky gene polymorphisms only among Caucasian.
|
26579801 |
2015 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
When stratifying for race, the data showed that the rs12953717</span> was associated with a significantly increased CRC risk under all genetic models in Caucasians.
|
23949881 |
2014 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNPs rs7229639 and rs4939827 explained approximately 1% of the familial relative risk of CRC</span> in East Asians.
|
24448986 |
2014 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the subgroup analysis by cancer types, SMAD7 rs12953717 polymorphism was significantly associated with colorectal cancer.
|
23472153 |
2013 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the population-based families, both SNPs rs12953717 (odds ratio, 1.29; 95% confidence interval, 1.12-1.49), and rs11874392 (odds ratio, 0.80; 95% confidence interval, 0.70-0.92) were associated with risk of colorectal cancer.
|
23560096 |
2013 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among those with CRC, the minor allele (G) in rs4939827 was significantly associated with poorer overall survival (hazards ratio, 1.20; 95% CI, 1.02-1.42).
|
23104301 |
2013 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results show association of rs4939827 with colorectal cancer</span> risk in Croatian population.
|
24066093 |
2013 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber).
|
22367214 |
2012 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Results from our case-control study and the meta-analysis collectively confirmed the significant association of the variant rs4939827 with increased risk of colorectal cancer.
|
22457752 |
2012 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Two previous genome-wide association studies identified three single nucleotide polymorphisms (SNPs) (rs4939827, rs12953717 and rs4464148) in SMAD7 to be associated with colorectal cancer in a Western population.
|
21221812 |
2011 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Two previous genome-wide association studies identified three single nucleotide polymorphisms (SNPs) (rs4939827, rs12953717 and rs4464148) in SMAD7 to be associated with colorectal cancer in a Western population.
|
21221812 |
2011 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, we found cumulative effects of three genetic factors (rs7758229, rs6983267, and rs4939827 in SMAD7) and one environmental factor (alcohol drinking) which appear to increase CRC risk approximately twofold.
|
21242260 |
2011 |