Gene: PALB2 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs118203998
rs118203998
PALB2
C 0.700 CausalMutation CLINVAR Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results. 28008555

2017
dbSNP: rs180177100
rs180177100
PALB2
A 0.700 CausalMutation CLINVAR Germline Mutations in Cancer Susceptibility Genes in a Large Series of Unselected Breast Cancer Patients. 28724667

2017
dbSNP: rs180177100
rs180177100
PALB2
A 0.700 CausalMutation CLINVAR Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer. 28024868

2017
dbSNP: rs180177110
rs180177110
PALB2
A 0.700 CausalMutation CLINVAR Frequency of pathogenic germline mutation in CHEK2, PALB2, MRE11, and RAD50 in patients at high risk for hereditary breast cancer. 27783279

2017
dbSNP: rs180177110
rs180177110
PALB2
A 0.700 CausalMutation CLINVAR Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel. 27798748

2017
dbSNP: rs180177115
rs180177115
PALB2
A 0.700 GeneticVariation CLINVAR A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation. 28240985

2017
dbSNP: rs180177122
rs180177122
PALB2
T 0.700 CausalMutation CLINVAR Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks. 28779002

2017
dbSNP: rs180177126
rs180177126
PALB2
C 0.700 CausalMutation CLINVAR Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks. 28779002

2017
dbSNP: rs180177132
rs180177132
PALB2
T 0.700 CausalMutation CLINVAR Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif. 28158555

2017
dbSNP: rs180177143
rs180177143
PALB2
G 0.700 CausalMutation CLINVAR PALB2 mutations in BRCA1/2-mutation negative breast and ovarian cancer patients from Poland. 28279176

2017
dbSNP: rs180177143
rs180177143
PALB2
G 0.700 CausalMutation CLINVAR Germline Mutations in Cancer Susceptibility Genes in a Large Series of Unselected Breast Cancer Patients. 28724667

2017
dbSNP: rs515726117
rs515726117
PALB2
A 0.700 CausalMutation CLINVAR Lost in translation: returning germline genetic results in genome-scale cancer research. 28454591

2017
dbSNP: rs515726123
rs515726123
PALB2
A 0.700 CausalMutation CLINVAR PALB2 mutations in BRCA1/2-mutation negative breast and ovarian cancer patients from Poland. 28279176

2017
dbSNP: rs515726123
rs515726123
PALB2
A 0.700 CausalMutation CLINVAR Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif. 28158555

2017
dbSNP: rs515726126
rs515726126
PALB2
TA 0.700 CausalMutation CLINVAR A high frequency of PALB2 mutations in Jamaican patients with breast cancer. 28194609

2017
dbSNP: rs587776413
rs587776413
PALB2
C 0.700 CausalMutation CLINVAR A high frequency of PALB2 mutations in Jamaican patients with breast cancer. 28194609

2017
dbSNP: rs587776416
rs587776416
PALB2
C 0.700 CausalMutation CLINVAR Germline Mutations in Cancer Susceptibility Genes in a Large Series of Unselected Breast Cancer Patients. 28724667

2017
dbSNP: rs587776416
rs587776416
PALB2
C 0.700 CausalMutation CLINVAR Genetic Cancer Risk Assessment for Breast Cancer in Latin America. 28453507

2017
dbSNP: rs587776426
rs587776426
PALB2
GT 0.700 CausalMutation CLINVAR Pathologic findings in breast, fallopian tube, and ovary specimens in non-BRCA hereditary breast and/or ovarian cancer syndromes: a study of 18 patients with deleterious germline mutations in RAD51C, BARD1, BRIP1, PALB2, MUTYH, or CHEK2. 28709830

2017
dbSNP: rs587776527
rs587776527
PALB2
A 0.700 CausalMutation CLINVAR Germline Mutations in Cancer Susceptibility Genes in a Large Series of Unselected Breast Cancer Patients. 28724667

2017
dbSNP: rs587781840
rs587781840
PALB2
C 0.700 CausalMutation CLINVAR Exome sequencing covers >98% of mutations identified on targeted next generation sequencing panels. 28152038

2017
dbSNP: rs587782005
rs587782005
PALB2
A 0.700 CausalMutation CLINVAR Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks. 28779002

2017
dbSNP: rs587782081
rs587782081
PALB2
T 0.700 CausalMutation CLINVAR Frequency of germline PALB2 mutations among women with epithelial ovarian cancer. 27631815

2017
dbSNP: rs730881872
rs730881872
PALB2
A 0.700 CausalMutation CLINVAR Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer. 28825143

2017
dbSNP: rs745533713
rs745533713
PALB2
G 0.700 CausalMutation CLINVAR Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks. 28779002

2017