rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
FTO genotypes associated with risk for obesity and loss of control of eating, specifically rs1421085, may interact with insecure attachment in a way that may exacerbate binge eating among women with BED.
|
30822753 |
2019 |
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
FTO SNPs rs1421085</span> and rs9939609 affect genetic susceptibility for obesity only in girls, whereas, SNP rs8057044 and CNV are associated with overweight status only in boys.
|
30537186 |
2019 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results suggested that FTO rs9939609, MC4R rs12970134, and MC4R rs17782313 are strongly associated with obesity.
|
30896429 |
2019 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, BDNF rs6265 and MC4R rs17782313 showed gender-dependent associations with decreased risk of having low HDL-C in males and increased risk of having abdominal obesity in females, respectively.
|
31502573 |
2019 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study pointed out the role of MC4R rs17782313 and ENPP1 rs1044498 genotypes in obesity determinisms in mothers and their newborns in correlation with BMI, MUAC, TST and bioimpedance parameters.
|
31350533 |
2019 |
rs8050136
|
|
|
0.900 |
GeneticVariation |
BEFREE |
An unweighted genetic risk score (GRS) was calculated for two <i>FTO</i> single-nucleotide polymorphisms (rs8050136 and rs2388405) by summation of the number of risk alleles for obesity.
|
31516636 |
2019 |
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The FTO SNP (rs1421085) results in a T to C nucleotide substitution that may result in an increased risk for obesity in individuals who carry at least one C allele.
|
30124167 |
2018 |
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The FTO polymorphisms were associated with a significantly increased risk for obesity and in BMI-stratified cohort, rs9939609 (T/A: odds ratio [OR] = 1.73, p = 0.007) and rs1421085 (T/C: OR = 1.56, p = 0.03) showed even stronger association.
|
29466028 |
2018 |
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
BACKGROUND The distribution of fat mass and obesity-associated gene (FTO) genes rs9939609 and rs1421085 in obese and normal ethnic Mongolians was analyzed to investigate the association of FTO gene polymorphisms with obesity and metabolic syndrome in ethnic Mongolians.
|
30442880 |
2018 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Women with extreme obesity carrying rs17782313 MC4R polymorphism present a higher pre-surgical BMI, are more unlikely to reach non-obesity BMI (<30 kg/m<sup>2</sup>) and tend to maintain a BMI > 35 kg/m<sup>2</sup> that characterize treatment failure.
|
28579220 |
2018 |
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This indicates that the rs1421085-C allele in FTO induces obesity likely via other pathways than via reduced FatOx.
|
28626215 |
2017 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Impact of the Polymorphism Near <i>MC4R</i> (rs17782313) on Obesity- and Metabolic-Related Traits in Women Participating in an Aerobic Training Program.
|
28828082 |
2017 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs17782313 C allele is associated with eating behavior traits that may predispose obese children to increased energy intake and obesity.
|
27730429 |
2017 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
<i>Purpose</i>.Genome-wide association studies have found two obesity-related single-nucleotide polymorphisms (SNPs), rs17782313 near the melanocortin-4 receptor (<i>MC4R</i>) gene and rs6265 near the brain-derived neurotrophic factor (<i>BDNF</i>) gene, but the associations of both SNPs with other obesity-related traits are not fully described, especially in children.
|
28396685 |
2017 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To further elucidate the role of genetics in obesity onset, we performed a candidate-gene association study in a young and sportive Italian population by testing the association of functional polymorphisms in ACE (rs4646994), FTO (rs9939609), MC4R (rs17782313) and PPARG (rs1801282) genes with body mass index (BMI) and waist-to-height ratio (WHtR).
|
28090739 |
2017 |
rs8050136
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a case-control study with 829 participants, factors involved with metabolism and obesity were assessed, including biochemical lipid and liver markers, and the fat mass and obesity-associated (FTO) single nucleotide polymorphism (SNP) rs8050136.
|
27905213 |
2017 |
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In single locus analysis, FTO rs8050136 CA (p = 0.0001; OR (95% CI) = 2.4 (1.7-3.4) and AA (p = 0.0001; OR (95% CI) = 3.1 (1.9-5.2); FTO rs1421085 TA (p = 0.0001; OR (95% CI) = 2.1 (1.4-3.0) and AA (p = 0.0001; OR (95% CI) = 3.0 (1.8-5.0); FTO rs9939609 TC (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and CC (p = 0.0001; OR (95% CI) = 4.2 (2.5-7.3) along with TG (p = 0.001; OR (95% CI) = 2.1 (1.3-3.2) and GG (p = 0.021; OR (95% CI) = 3.8 (1.2-11.8) genotypes of FTO rs17817449 with GT (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and TT (p = 0.012; OR (95% CI) = 3.3 (1.8-3.6) genotypes of IRX3 rs3751723 were significantly associated with obesity.
|
26440677 |
2016 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To investigate the association between the fat mass and obesity related (FTO) gene rs9939609 and near melanocortin-4-receptor (MC4R) gene rs17782313 polymorphisms with obesity measures and metabolic parameters in urban and rural dwelling Sri Lankans.
|
26948330 |
2016 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians.
|
26226973 |
2016 |
rs8050136
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In single locus analysis, FTO rs8050136 CA (p = 0.0001; OR (95% CI) = 2.4 (1.7-3.4) and AA (p = 0.0001; OR (95% CI) = 3.1 (1.9-5.2); FTO rs1421085 TA (p = 0.0001; OR (95% CI) = 2.1 (1.4-3.0) and AA (p = 0.0001; OR (95% CI) = 3.0 (1.8-5.0); FTO rs9939609 TC (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and CC (p = 0.0001; OR (95% CI) = 4.2 (2.5-7.3) along with TG (p = 0.001; OR (95% CI) = 2.1 (1.3-3.2) and GG (p = 0.021; OR (95% CI) = 3.8 (1.2-11.8) genotypes of FTO rs17817449 with GT (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and TT (p = 0.012; OR (95% CI) = 3.3 (1.8-3.6) genotypes of IRX3 rs3751723 were significantly associated with obesity.
|
26440677 |
2016 |
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNPs rs1421085, rs17817449 and rs8043757 in the first intron of the FTO gene are associated with increasing risk of obesity in Thais.
|
25542809 |
2015 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings indicated that rs17782313, rs543874, rs2241423 and rs11084753 were associated with the risk for children obesity in China, and interaction of genetic variants with diet behaviors on obesity.
|
25637721 |
2015 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Rs9939609 and rs17782313 are associated with PCOS and obesity-related traits and profiles.
|
26032905 |
2015 |
rs8050136
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A region in the first intron of the fat mass- and obesity-associated (FTO) gene, encompassing markers rs9939973, rs8050136, and rs9939609, has been consistently associated with obesity and body mass index (BMI) in different populations.
|
26529281 |
2015 |
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The FTO rs1421085 T>C polymorphism may modulate the magnitude of dyslipidemia in Chinese early-onset obesity.
|
24331679 |
2014 |