Gene: TMEM175 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6599388
rs6599388
TMEM175
0.810 GeneticVariation BEFREE The genotypic frequency of rs591323 differed significantly between the patient and control groups; however, neither rs6599388 nor rs142821586 was associated with PD. 26535683

2015
dbSNP: rs6599388
rs6599388
TMEM175
0.810 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815

2012
dbSNP: rs6599388
rs6599388
TMEM175
T 0.810 GeneticVariation GWASCAT Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. 21292315

2011
dbSNP: rs6599388
rs6599388
TMEM175
T 0.810 GeneticVariation GWASDB Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. 21292315

2011
dbSNP: rs6599389
rs6599389
TMEM175
A 0.800 GeneticVariation GWASCAT Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487

2011
dbSNP: rs6599389
rs6599389
TMEM175
A 0.800 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487

2011
dbSNP: rs34311866
rs34311866
TMEM175
0.730 GeneticVariation BEFREE Two coding variants, TMEM175 p.M393T (odds ratio [OR] = 1.37, p = 0.0003) and p.Q65P (OR = 0.72, p = 0.005), were associated with PD, and p.M393T was also associated with RBD (OR = 1.59, p = 0.001). 31658403

2020
dbSNP: rs34311866
rs34311866
TMEM175
C 0.730 GeneticVariation GWASCAT Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms. 30957308

2019
dbSNP: rs34311866
rs34311866
TMEM175
0.730 GeneticVariation BEFREE These results suggest that the main signal in the chromosome 4p16.3 PD risk locus is driven by the TMEM175 p.M393T variant. 31261387

2019
dbSNP: rs34311866
rs34311866
TMEM175
C 0.730 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci. 28892059

2017
dbSNP: rs34311866
rs34311866
TMEM175
0.730 GeneticVariation BEFREE Here, in order to discover potential AD-related loci, we investigated the association between late-onset AD (LOAD) susceptibility and nine single-nucleotide polymorphisms (SNPs) (rs11724635 of BST1, rs12637471 of MCCC1, rs15553999 of TMEM229, rs17649553 of MAPT, rs34311866 of TMEM175-GAK-DGKQ, rs356182 of SNCA, rs6430538 of ACMSD-TMEM163, rs76904798 of LRRK2 and rs823118 of RAB7L1-NUCKS1) which were reported to have genome-wide significant associations with PD risk in a recent Genome Wide Association Study performed among white population. 26738859

2017
dbSNP: rs34311866
rs34311866
TMEM175
C 0.730 GeneticVariation GWASCAT Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. 25064009

2014
dbSNP: rs34884217
rs34884217
TMEM175
0.010 GeneticVariation BEFREE Two coding variants, TMEM175 p.M393T (odds ratio [OR] = 1.37, p = 0.0003) and p.Q65P (OR = 0.72, p = 0.005), were associated with PD, and p.M393T was also associated with RBD (OR = 1.59, p = 0.001). 31658403

2020
dbSNP: rs142821586
rs142821586
TMEM175
0.010 GeneticVariation BEFREE The genotypic frequency of rs591323 differed significantly between the patient and control groups; however, neither rs6599388 nor rs142821586 was associated with PD. 26535683

2015