rs121908448
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Inhibition of endogenous WRN, through co-expression of WRN(K577M), diminishes recruitment of p300/CREB-binding protein-associated factor (PCAF) and positive transcription elongation factor b (P-TEFb) to Tat/transactivation response-RNA complexes, and immortalized WRN(-/-) WS fibroblasts exhibit comparable defects in recruitment of PCAF and P-TEFb to the HIV-1 LTR.
|
17317667 |
2007 |
rs121908448
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Primary tail fibroblast cultures from K577M-WRN mice showed three characteristics of WS cells: hypersensitivity to 4-nitroquinoline-1-oxide (4NQO), reduced replicative potential, and reduced expression of the endogenous WRN protein.
|
10628995 |
2000 |
rs121908448
|
|
T |
0.720 |
CausalMutation |
CLINVAR |
|
|
|
rs747319628
|
|
T |
0.710 |
CausalMutation |
CLINVAR |
A WS patient with an Arg987Ter mutation has been previously reported in Switzerland, the present case is the first to be identified in Asia.
|
22188495 |
2012 |
rs747319628
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A WS patient with an Arg987Ter mutation has been previously reported in Switzerland, the present case is the first to be identified in Asia.
|
22188495 |
2012 |
rs747319628
|
|
T |
0.710 |
GeneticVariation |
CLINVAR |
A WS patient with an Arg987Ter mutation has been previously reported in Switzerland, the present case is the first to be identified in Asia.
|
22188495 |
2012 |
rs747319628
|
|
T |
0.710 |
GeneticVariation |
CLINVAR |
The spectrum of WRN mutations in Werner syndrome patients.
|
16673358 |
2006 |
rs17847577
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
Clinical utility gene card for: Werner Syndrome--Update 2014.
|
25182132 |
2015 |
rs17847577
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.
|
25390333 |
2014 |
rs763089663
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations.
|
20443122 |
2010 |
rs776785728
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis.
|
18810497 |
2008 |
rs113993961
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
The spectrum of WRN mutations in Werner syndrome patients.
|
16673358 |
2006 |
rs1281075870
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
The spectrum of WRN mutations in Werner syndrome patients.
|
16673358 |
2006 |
rs143916053
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
The spectrum of WRN mutations in Werner syndrome patients.
|
16673358 |
2006 |
rs1554519449
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
The spectrum of WRN mutations in Werner syndrome patients.
|
16673358 |
2006 |
rs1563341296
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
The spectrum of WRN mutations in Werner syndrome patients.
|
16673358 |
2006 |
rs1563376793
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
The spectrum of WRN mutations in Werner syndrome patients.
|
16673358 |
2006 |
rs17847577
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
The spectrum of WRN mutations in Werner syndrome patients.
|
16673358 |
2006 |
rs17847577
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
Werner syndrome and mutations of the WRN and LMNA genes in France.
|
16786514 |
2006 |
rs267607008
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
The spectrum of WRN mutations in Werner syndrome patients.
|
16673358 |
2006 |
rs387906337
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
The spectrum of WRN mutations in Werner syndrome patients.
|
16673358 |
2006 |
rs772319506
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
The spectrum of WRN mutations in Werner syndrome patients.
|
16673358 |
2006 |
rs777096501
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
The spectrum of WRN mutations in Werner syndrome patients.
|
16673358 |
2006 |
rs878854131
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Werner syndrome and mutations of the WRN and LMNA genes in France.
|
16786514 |
2006 |
rs878854131
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
Werner syndrome and mutations of the WRN and LMNA genes in France.
|
16786514 |
2006 |