Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5275
rs5275
0.020 GeneticVariation BEFREE Our meta-analysis demonstrated that COX-2 rs5275 and rs689466 polymorphism significantly decrease the risk of lung cancer in Asians but not in Caucasians, indicating COX-2 could serve as a potential diagnostic marker for lung cancer. 30170377

2018

dbSNP: rs689466
rs689466
0.020 GeneticVariation BEFREE Our meta-analysis demonstrated that COX-2 rs5275 and rs689466 polymorphism significantly decrease the risk of lung cancer in Asians but not in Caucasians, indicating COX-2 could serve as a potential diagnostic marker for lung cancer. 30170377

2018

dbSNP: rs20417
rs20417
0.020 GeneticVariation BEFREE RESULTS COX-2 rs20417 polymorphism had a significant association with reduced risk of lung cancer under homozygous and recessive models, and similar results were observed in white and population-based subgroups under 2 and 3 contrasts, respectively. 26624903

2015

dbSNP: rs2066826
rs2066826
0.020 GeneticVariation BEFREE Additionally, rs2066826 polymorphism manifested a strong correlation with increased risk of lung cancer under 5 genetic models. 26624903

2015

dbSNP: rs20417
rs20417
0.020 GeneticVariation BEFREE The aim of this study was to investigate the association of five extensively-studied polymorphisms in PTGS2 (rs689466, rs5275, rs20417) and CYP2E1 (rs2031920, rs6413432) genes with lung cancer risk in a large northeastern Chinese population. 22761909

2012

dbSNP: rs5275
rs5275
0.020 GeneticVariation BEFREE The risk for lung cancer associated with the rs5275-C mutant allele was decreased by 60% (95% CI [confidence interval]: 0.21-0.74; P = 0.004) under the recessive model. 22761909

2012

dbSNP: rs689466
rs689466
0.020 GeneticVariation BEFREE Carriers of rs689466-G mutant allele had a 28% (95% CI: 0.57-0.92; P = 0.008) reduced risk of developing lung cancer relative to the AA genotype carriers. 22761909

2012

dbSNP: rs2066826
rs2066826
0.020 GeneticVariation BEFREE The Cox-2 intron 6 (rs2066826) genotypes were distributed differently between the lung cancer and control groups. 20530427

2010

dbSNP: rs200479241
rs200479241
0.010 GeneticVariation BEFREE IL-10 1082G/A, 819C/T and 592C/A polymorphisms might be risk factors for LC. 22160576

2012