Schizophrenia
|
0.360 |
Biomarker
|
disease |
BEFREE |
Our data suggest that HDAC1 inhibition should be considered as a therapeutic approach to treat schizophrenia.
|
28533418 |
2017 |
Schizophrenia
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
We used >700 well-characterized samples from patients diagnosed with schizophrenia (n = 175), major depressive disorder (n = 135), and bipolar disorder (n = 61) to measure HDAC1 and HDAC2 transcript levels by quantitative real-time PCR in dorsolateral prefrontal cortex (DLPFC) and caudate compared to control samples.
|
27959513 |
2017 |
Schizophrenia
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Several of the genes in this network including epigenetic factors histone deacetylase 1 (HDAC1) and death-associated protein 6 (DAXX), the GABAergic enzyme GAD65 as well as the kainate receptor (KAR) subunits GluR6 and 7 show significant changes in expression in this area in SZ.
|
27733539 |
2017 |
Schizophrenia
|
0.360 |
Biomarker
|
disease |
BEFREE |
To characterize the contribution of these factors to the developmental perturbation hypothesized to underlie SZ, lentiviral vectors carrying short hairpin RNA interference (shRNAi) for HDAC1 and DAXX were used.
|
26812044 |
2016 |
Schizophrenia
|
0.360 |
Biomarker
|
disease |
PSYGENET |
Postmortem brain studies have shown that HDAC1-a lysine deacetylase with broad activity against histones and nonhistone proteins-is frequently expressed at increased levels in prefrontal cortex (PFC) of subjects diagnosed with schizophrenia and related disease.
|
23664640 |
2013 |
Schizophrenia
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
In summary, we suggest that reduced p35 expression in schizophrenia has an impact on synaptic protein expression and cognition and that these deficits can be rescued, at least in part, by the inhibition of histone deacetylase 1.
|
21772061 |
2011 |
Schizophrenia
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels.
|
17961987 |
2008 |
Schizophrenia
|
0.360 |
AlteredExpression
|
disease |
LHGDN |
The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels.
|
17961987 |
2008 |
Schizophrenia
|
0.360 |
Biomarker
|
disease |
PSYGENET |
The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels.
|
17961987 |
2008 |
Squamous cell carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.
|
21527555 |
2011 |
Squamous cell carcinoma
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.
|
21527555 |
2011 |
Squamous cell carcinoma
|
0.320 |
AlteredExpression
|
disease |
LHGDN |
Histone H4 acetylation and histone deacetylase 1 expression in esophageal squamous cell carcinoma.
|
12579268 |
2003 |
MYELODYSPLASTIC SYNDROME
|
0.310 |
AlteredExpression
|
group |
BEFREE |
Apoptotic cells significantly increased in both types of MDS. mRNA and protein levels of HDAC1 and TLR2 were reduced, whereas GATA-1 was increased in both types of MDS.
|
28963909 |
2017 |
MYELODYSPLASTIC SYNDROME
|
0.310 |
Biomarker
|
group |
CTD_human |
Apoptotic cells significantly increased in both types of MDS. mRNA and protein levels of HDAC1 and TLR2 were reduced, whereas GATA-1 was increased in both types of MDS.
|
28963909 |
2017 |
Endometrioma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Histone deacetylase-1 target mRNAs that were up-regulated by valproic acid (VPA) treatment in endometriotic cyst stromal cells (ECSCs) were identified by a global mRNA microarray technique.
|
23833041 |
2013 |
Endometriosis
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
HDAC1 and HDAC2 are differentially expressed in endometriosis.
|
22344732 |
2012 |
Endometriosis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis.
|
22138541 |
2012 |
Endometrioma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis.
|
22138541 |
2012 |
Hematopoetic Myelodysplasia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Effects of arsenic disulfide on apoptosis, histone acetylation, toll like receptor 2 activation, and erythropoiesis in bone marrow mononuclear cells of myelodysplastic syndromes patients in vitro.
|
28963909 |
2017 |
Mood Disorders
|
0.300 |
Biomarker
|
group |
PSYGENET |
These results provide evidence that selective inhibition of HDAC1 and HDAC2 in brain may provide an epigenetic-based target for developing improved treatments for mood disorders and other brain disorders with altered chromatin-mediated neuroplasticity.
|
23967191 |
2013 |
Familial primary pulmonary hypertension
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
|
22711276 |
2012 |
PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
|
22711276 |
2012 |
Pulmonary Hypertension, Primary, Fenfluramine-Associated
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
|
22711276 |
2012 |
Idiopathic pulmonary arterial hypertension
|
0.300 |
Biomarker
|
disease |
CTD_human |
HDAC1 and HDAC5 protein levels were elevated in lungs from human idiopathic pulmonary arterial hypertension and in lungs and right ventricles from rats exposed to hypoxia.
|
22711276 |
2012 |
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
|
22711276 |
2012 |