Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 9 11
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 26 10
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 3 3
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 20 39
MAPK14 Q16539 mitogen-activated protein kinase 14 Kinase 0.37 0.379 0.923 7 2
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 1 8
ALK Q9UM73 ALK receptor tyrosine kinase Kinase 3.2E-06 0.396 0.846 13 6
HLA-DQB1 P01920 major histocompatibility complex, class II, DQ beta 1 Immune response 8.9E-03 0.407 0.885 33 30
CASR P41180 calcium sensing receptor G-protein coupled receptor 4.7E-02 0.410 0.846 4 7
CDKN2B P42772 cyclin dependent kinase inhibitor 2B 7.3E-03 0.417 0.769 5 3
MAP2K7 O14733 mitogen-activated protein kinase kinase 7 Kinase 1.00 0.419 0.808 1 1
ABO P16442 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Enzyme 0.427 0.885 61 54
HMGA2 P52926 high mobility group AT-hook 2 Nucleic acid binding 0.87 0.429 0.808 12 15
PTPN22 Q9Y2R2 protein tyrosine phosphatase non-receptor type 22 3.5E-21 0.438 0.846 34 1
POU5F1 Q01860 POU class 5 homeobox 1 0.95 0.441 0.846 14 11
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 4 6
ETS1 P14921 ETS proto-oncogene 1, transcription factor Transcription factor 0.78 0.444 0.731 24 18
INS P01308 insulin 0.30 0.445 0.923 3 1
FOXP1 Q9H334 forkhead box P1 1.00 0.460 0.808 33 33
HNF4A P41235 hepatocyte nuclear factor 4 alpha Nuclear receptor 0.15 0.461 0.808 18 9
TH P07101 tyrosine hydroxylase 1.7E-06 0.462 0.885 2 5
FBXW7 Q969H0 F-box and WD repeat domain containing 7 Enzyme modulator 1.00 0.465 0.808 4 4
NOX4 Q9NPH5 NADPH oxidase 4 Enzyme 5.8E-20 0.471 0.885 9 11
GLP1R P43220 glucagon like peptide 1 receptor G-protein coupled receptor 0.29 0.471 0.846 4 3