Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 20
POLE Q07864 DNA polymerase epsilon, catalytic subunit 8.0E-27 0.526 0.731 12
MUTYH Q9UIF7 mutY DNA glycosylase Enzyme 1.3E-18 0.521 0.769 8
ERBB3 P21860 erb-b2 receptor tyrosine kinase 3 Kinase 1.7E-15 0.448 0.808 20
CASP10 Q92851 caspase 10 Enzyme 4.6E-12 0.528 0.692 7
ATR Q13535 ATR serine/threonine kinase Kinase 3.5E-09 0.456 0.923 16
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 22
CDH1 P12830 cadherin 1 0.15 0.401 0.808 7
AXIN2 Q9Y2T1 axin 2 0.57 0.507 0.692 8
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 13
KLF6 Q99612 Kruppel like factor 6 Nucleic acid binding 0.98 0.501 0.846 8
IRF1 P10914 interferon regulatory factor 1 Transcription factor 0.99 0.468 0.769 6
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 15
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 18
UBR5 O95071 ubiquitin protein ligase E3 component n-recognin 5 1.00 0.597 0.654 8