Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 6
IL6 P05231 interleukin 6 0.32 0.248 0.962 8
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 7
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 7
IFNG P01579 interferon gamma 0.47 0.288 0.962 9
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 5
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 4
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 4
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 7
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 3
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 5
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 10
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 10
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 3
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 6
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 3
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 10
LEP P41159 leptin 0.46 0.349 0.846 10
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923 3
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 3
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 3
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 5
CD34 P28906 CD34 molecule 5.0E-06 0.368 0.808 4
CTLA4 P16410 cytotoxic T-lymphocyte associated protein 4 0.94 0.369 0.923 4