Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 3
IL6 P05231 interleukin 6 0.32 0.248 0.962 8
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 7
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 3
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 5
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 3
IL17A Q16552 interleukin 17A 4.3E-02 0.324 0.923 2
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 10
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 2
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 10
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 4
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 10
LEP P41159 leptin 0.46 0.349 0.846 10
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 6
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 5
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923 3
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 3
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923 1
REN P00797 renin Enzyme 2.4E-07 0.370 0.923 6
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 4
GH1 P01241 growth hormone 1 Signaling 3.0E-02 0.373 0.923 3
ALK Q9UM73 ALK receptor tyrosine kinase Kinase 3.2E-06 0.396 0.846 4
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 2
VWF P04275 von Willebrand factor Enzyme modulator 3.2E-25 0.408 0.885 2