Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 39
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 1
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 28
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 8
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 23
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 20
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 1
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 33
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 1
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 7
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 10
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 4
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 22
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 9
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 6
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 3
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 1
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 2
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 1
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 9
MDM2 Q00987 MDM2 proto-oncogene Nucleic acid binding 1.00 0.362 0.846 4