Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
ROS1 P08922 ROS proto-oncogene 1, receptor tyrosine kinase Kinase 1.6E-72 0.439 0.885 1
FANCA O15360 FA complementation group A 1.6E-68 0.505 0.731 3
TET2 Q6N021 tet methylcytosine dioxygenase 2 4.3E-54 0.458 0.808 1
ECT2L Q008S8 epithelial cell transforming 2 like 7.8E-48 0.769 0.192 1
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 20
DNMT3A Q9Y6K1 DNA methyltransferase 3 alpha 7.4E-39 0.445 0.846 1
WRN Q14191 WRN RecQ like helicase Enzyme 2.6E-34 0.524 0.808 3
MSH3 P20585 mutS homolog 3 Nucleic acid binding 7.4E-31 0.474 0.769 1
FANCD2 Q9BXW9 FA complementation group D2 1.1E-30 0.479 0.885 2
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 14
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808 10
POLE Q07864 DNA polymerase epsilon, catalytic subunit 8.0E-27 0.526 0.731 12
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 16
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808 5
DPYD Q12882 dihydropyrimidine dehydrogenase Enzyme 3.4E-22 0.493 0.846 1
ERCC6 P0DP91 Q03468 ERCC excision repair 6, chromatin remodeling factor 5.2E-22 0.507 0.808 4
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846 10
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 8
MUTYH Q9UIF7 mutY DNA glycosylase Enzyme 1.3E-18 0.521 0.769 8
PMS1 P54277 PMS1 homolog 1, mismatch repair system component Nucleic acid binding 1.3E-17 0.569 0.654 8
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731 6
NBN O60934 nibrin Nucleic acid binding 2.2E-16 0.467 0.808 4
MCC P23508 MCC regulator of WNT signaling pathway 4.7E-16 0.568 0.731 1
MAD1L1 Q9Y6D9 mitotic arrest deficient 1 like 1 6.8E-16 0.570 0.731 2