Source: CLINVAR

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
ARAF P10398 A-Raf proto-oncogene, serine/threonine kinase Kinase 0.96 0.619 0.654 3 2
B2M P61769 beta-2-microglobulin Immune response 0.56 0.447 0.846 12 6
BCL2L12 Q9HB09 BCL2 like 12 3.8E-09 0.606 0.654 2 1
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 125 84
CASC11 cancer susceptibility 11 0.641 0.577 6 7
CDK4 P11802 cyclin dependent kinase 4 Kinase 6.3E-02 0.412 0.808 7 2
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 22 83
CNOT9 Q92600 CCR4-NOT transcription complex subunit 9 0.99 0.769 0.192 5 4
CREBBP Q92793 CREB binding protein 1.00 0.428 0.808 40 115
CRNKL1 Q9BZJ0 crooked neck pre-mRNA splicing factor 1 Nucleic acid binding 2.7E-06 0.711 0.385 2 1
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 70 52
CYP21A2 P08686 cytochrome P450 family 21 subfamily A member 2 2.6E-04 0.525 0.769 16 43
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 23 28
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 6 16
FBXW7 Q969H0 F-box and WD repeat domain containing 7 Enzyme modulator 1.00 0.465 0.808 18 7
GNA11 P29992 G protein subunit alpha 11 Enzyme modulator 0.89 0.563 0.731 5 8
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 0.68 0.420 0.885 60 27
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 71 21
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1 2.6E-12 0.424 0.808 18 2
IRF3 Q14653 interferon regulatory factor 3 Transcription factor 1.2E-04 0.517 0.808 3 2
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 21 66
KNSTRN Q9Y448 kinetochore localized astrin (SPAG5) binding protein 2.1E-06 0.729 0.500 2 1
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 66 35
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 Kinase 0.90 0.439 0.846 26 30