Source: UNIPROT

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
DCUN1D3 Q8IWE4 defective in cullin neddylation 1 domain containing 3 0.87 1 0
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 6 70
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 2 3
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 1 0
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 10 29
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 1 1
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 13 33
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 7 13
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 10 34
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 3 3
ALB P02768 albumin Transporter 0.64 0.317 0.962 1 2
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 10 32
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 1 1
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 8 18
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 2 6
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 2 3
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 2 5
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 4 4
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 2 4
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 1 47
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 4 11
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 6 19
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 1 3
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 1 0