Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 243
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 63
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 199
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 341
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 303
AKT1 P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.98 0.355 0.862 172
STAT3 P40763 signal transducer and activator of transcription 3 nucleic acid binding; transcription factor 1.00 0.358 0.862 89
IGF2 P01344 insulin like growth factor 2 4.7E-02 0.399 0.828 111
FGFR3 P22607 fibroblast growth factor receptor 3 1.8E-05 0.417 0.759 312
RET P07949 ret proto-oncogene 1.00 0.418 0.724 153
NRAS P01111 NRAS proto-oncogene, GTPase enzyme modulator 0.53 0.420 0.690 206
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit 1.00 0.421 0.759 112
BRCA2 P51587 BRCA2, DNA repair associated nucleic acid binding 5.5E-24 0.426 0.793 50
PTPN11 Q06124 protein tyrosine phosphatase, non-receptor type 11 1.00 0.429 0.828 168
PTCH1 Q13635 patched 1 1.00 0.435 0.759 146
TGFBR2 P37173 transforming growth factor beta receptor 2 kinase; receptor; transferase 0.15 0.437 0.793 99
CREBBP Q92793 CREB binding protein nucleic acid binding; transcription factor; transferase 1.00 0.451 0.862 189
ACTB P60709 actin beta cytoskeletal protein 0.99 0.453 0.862 147
FLNA P21333 filamin A 1.00 0.456 0.793 361
GLB1 P16278 galactosidase beta 1 hydrolase 7.6E-10 0.457 0.828 124
NF1 P21359 neurofibromin 1 enzyme modulator 1.00 0.458 0.724 91
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 0.91 0.459 0.759 152
SOX9 P48436 SRY-box 9 1.00 0.459 0.724 133
RAF1 P04049 Raf-1 proto-oncogene, serine/threonine kinase 0.89 0.462 0.793 122