Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MAP3K13 O43283 mitogen-activated protein kinase kinase kinase 13 Kinase 0.80 0.743 0.192 4
SMARCD1 Q96GM5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Nucleic acid binding 1.00 0.695 0.385 4
FGF4 P08620 fibroblast growth factor 4 Signaling 0.14 0.588 0.577 4
INPP4B O15327 inositol polyphosphate-4-phosphatase type II B 0.55 0.573 0.577 4
PBRM1 Q86U86 polybromo 1 Epigenetic regulator 1.00 0.566 0.615 5
MAP2K4 P45985 mitogen-activated protein kinase kinase 4 Kinase 1.00 0.559 0.692 9
HERC2 O95714 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1.00 0.568 0.692 4
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 14
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731 6
FOXA1 P55317 forkhead box A1 Transcription factor 0.22 0.522 0.731 5
NCOR1 O75376 nuclear receptor corepressor 1 Transcription factor 1.00 0.597 0.731 4
AKT2 P31751 AKT serine/threonine kinase 2 Kinase 0.64 0.474 0.769 15
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769 8
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 8
TBX3 O15119 T-box transcription factor 3 Transcription factor 0.99 0.525 0.769 4
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 15
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808 5
BTK Q06187 Bruton tyrosine kinase Kinase 1.00 0.464 0.808 5
FGF3 P11487 fibroblast growth factor 3 Signaling 9.3E-05 0.505 0.808 4
PDPK1 O15530 3-phosphoinositide dependent protein kinase 1 Kinase 0.98 0.588 0.808 4
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 16
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 12
ARID1A O14497 AT-rich interaction domain 1A 1.00 0.455 0.846 7