Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 16
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 15
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 12
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769 8
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 8
ARID1A O14497 AT-rich interaction domain 1A 1.00 0.455 0.846 7
ARID1B Q8NFD5 AT-rich interaction domain 1B 1.00 0.503 0.846 5
GATA3 P23771 GATA binding protein 3 0.90 0.415 0.846 4
INPP4B O15327 inositol polyphosphate-4-phosphatase type II B 0.55 0.573 0.577 4
HERC2 O95714 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1.00 0.568 0.692 4
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 14
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 14
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731 6
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 6
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 33
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 29
PBRM1 Q86U86 polybromo 1 Epigenetic regulator 1.00 0.566 0.615 5
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 22
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 20
AKT2 P31751 AKT serine/threonine kinase 2 Kinase 0.64 0.474 0.769 15
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 9